Sentences with phrase «rna nucleotide sequences»

Not exact matches

There is no such «direct» evolution: animals, bacteria, and algae have a common ancestor from which they have diverged, as can be shown by aligning and comparing amino acid sequences of proteins and nucleotide sequences of homologous ribosomal RNA molecules that are found in both bacteria and vertebrates.

Every tissue in an organism contains a variety of messenger RNA molecules, single - stranded nucleotide sequences bearing instructions for the making of specific proteins.

The nucleotide in M1 RNA, residue C92, which participates in a crosslink with the substrate was deleted and the resulting mutant M1 RNA was shown to cleave substrates lacking the 3» terminal CCAUCA sequence at sites several nucleotides away from the normal site of cleavage.

A catalytic RNA (ribozyme) derived from an intervening sequence (IVS) RNA of Tetrahymena thermophila will catalyze an RNA polymerization reaction in which pentacytidylic acid (C5) is extended by the successive addition of mononucleotides derived from a guanylyl -(3», 5»)- nucleotide (GpN).

In germline cells PIWI proteins silence the RNA from jumping genes by cutting them in sequences of ~ 30 nucleotides that will become piRNAs.

Next they copied the promising RNA molecules using a technique that caused small mutations in their nucleotide sequences and let these mutated RNA molecules have another go at the reaction.

Even if we assume that a trillion trillion trillion trillion unique sequences 180 nucleotides long could function as RNA replicases, the probability of hitting any one of them in a single shot is still only about 1 in 1060.

By using random series of 30 nucleotides — the building blocks of RNA and DNA — he thought he could give neurons unique barcodes, linking the barcodes across synapses, then create maps of their connections using high - throughput gene sequencing technology.

Extensive research has already examined the function of microRNAs, a category of small evolutionarily conserved noncoding RNAs about 22 to 24 nucleotides in length that target protein - coding genes in a sequence - specific manner.

They can copy only certain sequences of nucleotide bases, the building blocks that make up RNA and DNA, and those sequences don't carry out any important function inside cells.

The sugar alteration shortens the link between successive nucleotides by one atom, but a TNA molecule can still match its sequence with sequences of RNA and DNA, in addition to other molecules of TNA, the authors report in the 17 November issue of Science.

In some sequences, they systematically changed purine RNA nucleotides, containing the bases adenine or guanine, into the corresponding DNA purines.

These findings suggest that the cloned Acks cDNA also contained nucleotide sequences corresponding to the putative neural activity - inducible Acks transcript, and that, like the kakusei - transcript, the Acks transcript functions as a non-coding RNA.

Import, Processing, and Expression In their original report, (1) Teitell's group had identified 20 - nucleotide stem - loop import sequences in RNase P and MRP RNA that greatly facilitated their PNPase - dependent import into mitochondria.

The researchers analyzed hundreds of human transcription factors, which are proteins that read the genetic information coded in DNA's sequence of four nucleotide bases — adenine (A), cytosine (C), guanine (G) and thymine (T)-- and pass that on to RNA molecules.

When fused to the 5 ′ - terminus of the RNA for nucleotides that are not physiologically imported, these import sequences enabled their import into isolated yeast and human mitochondrial matrix, in a PNPase - dependent fashion.

«By combining different methods for RNA sequencing with new bioinformatics tools we could find novel sites of nucleotide base exchange, so - called editing», says Jens Lagergren, Professor at the Royal Institute of Technology and group leader at SciLifeLab Stockholm.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

There she developed an approach, native elongation transcript sequencing, NET - seq, that directly visualizes global transcriptional activity through mapping RNA polymerase density genome - wide with single - nucleotide resolution.

Kazuko Nishikura, Ph.D., discovered a mechanism of RNA regulation through which cells can make discrete changes in the sequence of nucleotides — the «letters» in the RNA code, ultimately affecting the protein product.

Thousands of nucleotides are linked together to form the DNA or RNA sequence chains.