Next, Grima looked at cell death in cultured neurons with a healthy or a mutant form of Huntingtin, or with a mutant form of Huntingtin that was treated with small amounts of an experimental drug called KPT - 350, one that prevents a nuclear export protein, Exportin - 1, from shuttling proteins and
RNA out of the nucleus.
Not exact matches
DNA never leaves the
nucleus of the cell; its molecular recipes are read
out in the form
of messenger
RNA, which leaves the
nucleus and enters the cytoplasm, where proteins are made.
RNA messages are copies
of small snippets
of DNA that move
out of the cell
nucleus to be converted into proteins.
RNA was once thought to be a mere middleman, carrying genetic messages from the DNA in the
nucleus out to cellular structures called ribosomes, where it directs the production
of proteins.
This process, known as gene expression, begins with transcription, in which a molecule called messenger
RNA transfers the information in DNA
out of the cell's
nucleus and into the cytoplasm, where it is translated into amino acids that form proteins.
The
RNA strand is then moved
out of the
nucleus where enzyme - like organelles called ribosomes use it as a guide to synthesize chains
of amino acids that form the desired protein.