Sentences with phrase «rna subunit»

The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which contains a short template for telomeric DNA synthesis.

The team found that the U6 RNA subunit directly controls catalytic function — effectively acting as the blade of the spliceosome.

M1 RNA, the catalytic RNA subunit of Escherichia coli ribonuclease P, can cleave novel transfer RNA (tRNA) precursors that lack specific domains of the normal tRNA sequence.

Ribonuclease P (RNase P) from Escherichia coli or its catalytic RNA subunit can efficiently cleave small RNA substrates that lack the conserved features of natural substrates of RNase P if an additional small RNA is also present.

Analysis of crosslinked complexes of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli, and transfer RNA precursor substrates has led to the identification of regions in the enzyme and in the substrate that are in close physical proximity to each other.

Not exact matches

Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved at between 3.1 and 3.3 angstroms resolution.

Structures of a 10 - subunit yeast RNA polymerase II have been derived from two crystal forms at 2.8 and 3.1 angstrom resolution.

Cognate transfer RNA (tRNA) binding induces global domain movements of the 30S subunit and changes in the conformation of the universally conserved and essential bases A1492, A1493, and G530 of 16S RNA.

Now, as Thomas Cech explains in his Perspective, atomic resolution of the structure of the large ribosomal subunit reveals that, as predicted by those convinced of a prebiotic RNA world, RNA is the catalytic component with proteins being the structural units that support and stabilize it (Ban et al., Nissen et al., Muth et al.).

Using the atomic structures of the large ribosomal subunit fromHaloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address the catalytic properties of its all - RNA active site.

In particular, there was a complex between the 40S ribosomal subunit and initiator tRNA that went away when heme was missing or double - stranded RNA was present.

Most of the proteins stabilize the structure by interacting with several RNA domains, often using idiosyncratically folded extensions that reach into the subunit's interior.

In particular, early life would have needed to synthesize nucleotides, the subunits of RNA and DNA, in order to reproduce itself.

This piece of DNA, called the 16S subunit of ribosomal RNA, does not change quickly over time, however, so it gives a very coarse timeline for the evolution of bacteria.

Using this method, a single subunit targeting to the target RNA or protein subunits that is unique and assenting for the organism, the organism will be disabled or die and thus, no longer able to cause disease.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

By targeting RNA or protein subunits that have multiple sites for inactivation, but that are inextricably linked, this method allows for killing or disabling the RNA or protein without requiring the inhibition of multiple pathways that might be used by the organism to remain active and viable (and thus, multiple drugs are not needed, as well).

The ribosome has two key subunits, made of proteins and RNA, that do the work of pulling together and assembling amino acids.

The team found that the subunit's two RNA molecules fit tightly together.

Earlier researchers had detected subunits of DNA and RNA, called nucleobases, in the meteorite.

The structure shows that two other exposed surfaces of DNA - bound TAP, called AR2 and AR3, make protein to protein contacts with the RNA polymerase β subunit and with sigma.

In Escherichia coli, the small ribosomal subunit has a sedimentation coefficient of 30S, and consists of a 16S RNA molecule of 1541 nucleotides complexed with 21 proteins.

RNA editing changes one of the information - carrying subunits of RNA from the nucleotide adenosine to one called inosine.

The conflict between these two views is resolved in this report of small - angle neutron scattering measurements on 30S subunits with and without protein S1, and on subunits reconstituted from deuterated 16S RNA and unlabeled proteins.

The branch uniting the fungi and animals is well - supported based on a number of molecular phylogenetic datasets, including the nuclear small subunit ribosomal RNA gene (Wainwright et al., 1993; Bruns et al. 1993), unique and shared sequence insertions in proteins such as elongation factor 1α (Baldauf and Palmer, 1993), entire mitochondrial genomes (Lang et al., 2002), and concatenated protein - coding genes (Steenkamp et al., 2006).

Weaver, B. K., Kumar, K. P. & Reich, N. C. Interferon regulatory factor 3 and CREB - binding protein / p300 are subunits of double - stranded RNA - activated transcription factor DRAF1.

No one knew if this tail — also known as the C - terminus of the alpha subunit — touches anything else in the core of the RNA polymerase complex.

Methods: To identify proteins that modulate transcription, PNNL scientists expressed a tagged alpha - subunit of RNA polymerase in the bacterium Shewanella oneidensis under controlled growth conditions.

It was suspected, but not known for certain, that fly as well as mouse Zucchini proteins were nucleases — enzymes that specialize in cleaving bonds between the nucleotide subunits of nucleic acids (DNA and RNA).

When Filer and coworkers used RNA interference (RNAi) to knock down the amount of the largest subunit of Pol III, rpc - 1, in C. elegans, the worm lived longer.

Specifically, we have shown that the condensin subunit Cnd2 binds directly to the most important general transcription factor, the TATA box - binding protein TBP, and that TBP recruits condensin molecules onto RNA polymerase III - transcribed genes and highly active Pol II - transcribed genes (many ribosomal protein genes) through the Cnd2 - TBP interaction (Figure A).

Nucleotide a subunit of DNA or RNA, composed of a base, a phosphate and a sugar molecule.

In eukaryotes, they consist of a small 40S and large 60S subunit, which carry the decoding and peptidyl transferase activity, respectively, and together comprise four ribosomal (r) RNAs (18S, 5.8 S, 25S and 5S rRNA) and 78 ribosomal proteins in yeast.

Phylogenetic analysis of complete small subunit ribosomal RNA coding region of Myxidium lieberkuehni: evidence that Myxozoa are Metazoa and related to the Bilateria.

The phylogeny of Myxosporea (Myxozoa) based on small subunit ribosomal RNA gene analysis.

Small subunit ribosomal RNA sequences link the cause of proliferative gill disease in channel catfish to Henneguya n. sp. (Myxozoa: Myxosporea).

Combined large and small subunit ribosomal RNA phylogenies support a basal position of the acoelomorph flatworms.