Hunter's breakthrough, which set the story in motion, was a product of basic research on a chicken
RNA tumor virus: the 1979 discovery of the first tyrosine kinase paved the way for our understanding of how cells perceive their environment and respond appropriately to growth signals.
At a time when gene therapy has been revived as a potent form of cancer treatment, a new approach would use nanoparticles, rather than
viruses, to deliver strands of DNA or
RNA to
tumors.
In preclinical research,
tumor cells lysed by coxsackievirus A21 (CVA21), a naturally occurring «common cold» ICAM - 1 — targeted
RNA virus, induced a secondary systemic host - generated antitumor immune response.
Tags for this Online Resume: Lentiviral Retroviral shRNA
RNA knockdown screens, Flow Cytometry, RTPCR, Immunopreciptations, Reporter assays, Cell based Assays, ELISA, Migration, Stable and Transient Transfections, Genomic and Proteomic Studies, Cloning, Transient siRNA knockdowns, Phenotyping Mammalian cell lines, Gene Overexpression, Subcloning to expression Vectors, Construct Stable Inducible Cell lines, Protein Kinase Assay, Pulse Chase Experiments, Transfection, Transduction, Transformation, Polyoma
virus DNA
tumor virus replication, Research Scientist, Cell Biology Protein Biochemistry Genetics Molecular Bioliogy Oncology Virology, FACS