Sentences with phrase «rnai gene silencing»

Our observations illustrate that an important component of genome plasticity in early development is the capacity to reverse heritable gene silencing decisions.

Please recognise that the recent progress in the field of RNA - based gene silencing has involved original scientific inquiry from research groups around the world.»

«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»

«Our approach to gene silencing has not been demonstrated before in such a powerful way for the treatment of brain cancers,» Stegh said.

In the Baulcombe lab, Voinnet analyzed the in vivo dynamics of gene silencing using transgenic plants, recombinant viruses, and fluorescence microscopy.

At almost the same time, he stumbled across what would later become his research field: the first observations of gene silencing, which had started to trickle through via transgenic plant experiments.

Determined to investigate, Voinnet specialized in plant molecular biology and, because gene silencing had also been reported in plants made resistant to viruses, plant pathology.

«David [Baulcombe]'s group developed a number of very interesting gene silencing systems at the time and Olivier was very good at seeing connections between these and designing elegant experiments to test them,» Hamilton, today a lecturer at the University of Glasgow in the United Kingdom, writes in an e-mail.

That role is especially important in a field as young as gene silencing, he says.

They want as much as $ 82 million paid to them — money they say they've lost in licenses and royalties on Hannon's discoveries in gene silencing and on a start - up company that couldn't launch because the discoveries were denied patents.

Scientists think that this gene silencing process, known as RNA interference (RNAi), might help the worms adapt to changing conditions.

One study revealed that gene silencing triggered by mild heat stress continued in future generations of these worms, even after the initial heat stress was gone.

2015 will see the start of the first human clinical trial of a gene silencing or huntingtin - lowering drug, which specifically aims to reduce production of mutant huntingtin in the brains of HD patients.

«Better RNA interference, inspired by nature: New nanoparticles offer best - ever gene silencing.»

A protein that is responsible for gene silencing (heterochromatin protein 1?)

But now, in a study appearing in the May 11 issue of Nature Nanotechnology, an MIT - led team reports achieving the most potent RNAi gene silencing to date in nonliver tissues.

Importantly, the small remnants of the messenger RNA can then function like additional microRNAs, binding to other copies of the messenger RNA, causing further gene silencing.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

That could be very helpful right now as we are testing a new generation of so - called «gene silencing» drugs that we hope will put the brakes on the condition.

An integrative approach to data generation includes strict validation criteria using gene silencing, paired antibodies, and fluorescently tagged proteins.

It is, in a sense, the opposite of gene silencing, but it's another proof point that validates the general concept of creating drugs that mute or amplify defective genes.

This form of gene silencing is triggered by a short piece of double - stranded RNA (the chemical cousin to DNA) that matches the gene.

And many companies began to crumble: While gene silencing was simple in worms, mammals proved to be far more complex — and safe drug delivery emerged as a major problem.

In two new studies, a team of researchers led by Eva Nogales, senior faculty scientist in the Molecular Biophysics and Integrated Bioimaging (MBIB) Division, has gained insight into the structure of PRC2 and the ways in which it is regulated to affect gene silencing.

This work is complemented by a second study that presents snapshots of PRC2 binding to the histone proteins that it modifies as a signal for gene silencing.

ASCB President Don Cleveland of the University of California, San Diego, said his team just published an animal study on a gene silencing therapy for treating a form of Lou Gehrig's disease that they now hope to move to clinical studies.

Tycko studies a phenomenon called gene silencing, in which one of a person's two copies of a gene is shut off.

When the researchers silenced the genes in the peripheral nerves of adult animals, they were still hypersensitive to light touch, but they didn't display the behavioral abnormalities seen in the animals that had the gene silenced from birth.

On its own, gene silencing is also being used to create GM crops.

McKay and Tsai turned off production of the gene's protein through a technique known as gene silencing, and in other cases they added extra protein to the cells.

«If cells with a certain gene silenced disappear, for example, it means that gene is essential for proliferation.»

Our and previous findings suggest that both HDACs and cytosine methylation contribute to HIV - 1 latency, in agreement with a growing body of evidence demonstrating cooperation between these two gene silencing mechanisms [55], [56].

A major effort in the lab is to elucidate the active components of this process and to apply transcriptional gene silencing in a therapeutic setting.

RNA interference, or gene silencing, is a way to destroy specific RNA messages so that a particular protein is not made.

First author Dr Reza Haqshenas said the researchers then used gene silencing technology to determine whether the genes» cell factors identified using the antibody microarray were indeed important for HCV replication and therefore potential targets for anti-HCV compounds.

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo.

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

A type of gene silencing treatment in which specially designed DNA molecules are used to switch off a gene

Dr Carroll, who edited the article, has previously undertaken RNA - targeted Huntington's disease gene silencing research, and is named in an associated patent.

LADs themselves are instead associated with gene - poor regions and gene silencing [43, 44].

If what you've read here about zinc finger technology reminds you of «gene silencing» or «huntingtin - lowering» methods for treating Huntington's disease, give yourself a gold star.

Gene silencing is a natural adaptive defense mechanism used by plants against viruses.

A type of gene silencing treatment in which specially designed RNA molecules are used to switch off a gene

Toni Bedalov investigates drug candidates for anticancer therapy in breast - cancer malignancies, illuminates the molecular process of gene silencing

What these groups are attempting basically is «gene silencing», with a twist - it's aimed directly at the DNA, rather than targeting a «message molecule» called RNA.

These include gene silencing strategies and strictly virus - inducible resistance genes that will have no impact on food quality and safety.

In addition, A-to-I RNA editing is involved in control of the expression and function of microRNA (miRNA), which is a small RNA essential for the RNAi mediated gene silencing mechanism.

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

How HD gene silencing is supposed to work.

Today brings news that the first Huntington's Disease patients have been successfully dosed with gene silencing drugs targeting the HD gene.