Sentences with phrase «ros damage»

ROS damage to neurons has been implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative conditions.

On the other hand ROS damages are counteracted in the mitochondria by SIRT3 activation that improve SOD2 activity during CR 23.

Based on the previous evidences, it rusults important to maintain cellular NAD + availability especially in mitochondria when stresses induce a major consumption of NAD + and ATP and prone the organism more susceptible to ROS damages.

Not exact matches

In liver disease, excessive ROS triggers the activation of HSCs that, in turn, cause damage to liver tissues.

It belongs to a group of chemicals called reactive oxygen species (ROS), which scientists suspect to have a damaging effect on cells and their components.

This metabolic demand makes brain cells particularly vulnerable to damage from oxidative stress, in which reactive oxygen species (ROS), sometimes called free radicals, exert toxic effects on cellular components.

«The ROS creates a local signaling loop that allows just enough calcium to enter the mitochondria and turn on energy production without causing damage.

Now, researchers have developed tools to study these ephemeral molecules in small quarters of the cell, and using these techniques, have shown that the cell manages the conflicting effects of ROS by sequestering the molecule to tiny compartments or nanodomains where it acts locally, without damaging surrounding organelles or DNA.

While reactive oxygen species (ROS), can damage and kill cells — these molecules have also been implicated in normal biochemical processes.

Under the hypoxic conditions, the body might produce more reactive oxygen species (ROS), harmful compounds that can damage DNA.

Glutathione is a well - known antioxidant that prevents damage to important cellular components by ROS.

However, excessive generation of ROS and / or a fall in antioxidant defences can lead to indiscriminate damage, resulting in cellular oxidative stress [27].

Reactive oxygen species (ROS) induce cellular damages at different levels (proteins, DNA, and lipids) which increase the body susceptibility to noxious injuries with the final result to accelerate aging and decrease lifespan.

Inhibition of ROS induced by reflux may be a useful strategy for preventing DNA damage and decreasing the risk for tumor formation caused by GERD, they concluded.

Now in a study published in the journal Scientific Reports, Alexander Zaika, Ph.D. and coworkers show that DNA damage in the esophageal cells caused by acidic bile reflux (BA / A) activates enzymes called NADPH oxidases in the mitochondria, the cell's power house, to release highly reactive - oxygen species (ROS).

Inhibition of ROS elevation and damage on mitochondrial function prevents lead - induced neurotoxic effects on structures and functions of AFD neurons in Caenorhabditis elegans.

The response to damage induced by ROS is mediated by SIRT1 in the nuclear while in the mitochondria is mediated by SIRT3.

That finding suggested that the Ro / Y RNA complex plays a role in protecting against damage from ultraviolet radiation and could be compromised in lupus patients.

Exposure of tumor cells to clinically relevant low doses of ionizing radiation causes DNA damage and the generation of reactive oxygen species (ROS).

Glycogen synthase kinase - 3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production..

«It's clear that at high levels, ROS molecules can damage proteins, promoting aging and worsening disease states,» he says.

«But blindly consuming large doses of antioxidants is probably not the best idea, because while your intent would be to protect yourself from damage, you're also potentially interfering with normal ROS signals that are helpful and important.»

Anti-cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage.

A major cause of aging is increased oxidative damage caused by ROS.

She also found that reactive oxygen species, (ROS), which can cause tissue damage, play a role in the process.

High levels of ROS could cause oxidative damage to tissue.

Catalase is a very important enzyme which protects the cell from oxidative damage by ROS.

Despite the presence of the cell's antioxidant defense system to counteract oxidative damage from ROS, oxidative damage accumulates during the life cycle and has been implicated in aging and age - dependent diseases such as cardiovascular disease, cancer, neurodegenerative disorders and other chronic conditions.

So by replacing carbs with healthy fats, your cells» mitochondria are less likely to suffer damage from free radicals that are caused by reactive oxygen species or ROS.

Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) are known as «free radicals» and have been shown to cause damage and death to the cells they come in contact with.

Large amounts of ROS in the body leads to cell damage and increased inflammation.

The resulting drop in glutathione production and intracellular glutathione concentrations compromises the mitochondria's ability to scavenge reactive oxygen species (ROS), producing a vicious cycle that drives the progressive increase in ROS - mediated structural damage and its corollary, the progressive decline in energy production and repair that accompanies aging.

Abnormal Krebs cycle and / or oxidative phosphorylation cause (s) not only glucose hypometabolism but also the increased generation of reactive oxygen species (ROS), oxidative damage, and programmed cell death such as apoptosis.

However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damage.

ROS which is produced in high quantities when you eat the Standard American Diet damage your brain, organs, and mitochondrial leading to chronic diseases.

Most significantly, Tang - kuei is a natural source of ferulic acid, a potent antioxidant that protects cells from damaging reactive oxygen species (ROS).

ROS doesn't necessary damage the cell directly but the mitochondria it's self — specifically their DNA.

However, during times of disease, exercise, or environmental stress (e.g. smoking, sunlight or heat exposure) ROS levels can increase dramatically, which can result in significant damage to cell structures.

But the process of producing ATP creates a huge burst of damaging free radicals known as reactive oxygen species (ROS), which are the chief cause of mitochondria destruction.

However, during times of disease, exercise, or environmental stress (e.g. smoking, UV or heat exposure) ROS levels can increase dramatically, which can result in significant damage to cell structures.

The presence of too many ROS / free radicals leads to oxidative damage to the molecules in our cells including lipids, proteins and DNA, and this in turn can destroy cell function.

Free radicals or ROS can damage the membranes of the sperm cell, affecting sperm motility.

Inflammation in the intestines produces damaging reactive oxygen species (ROS) which initiate DNA damage, reduces oxygen flow to tissue and results in the further generation of pro-inflammatory cytokines and injury.

Liability: Roslindale Open Studios (ROS) is not responsible for loss or damage to artwork or other personal property sustained during the Roslindale Open Studios (ROS).

A v B: Chris was instructed on behalf of the Defendant sellers in this dispute arising out of the sale of a Ro - Ro car ferry which suffered major engine damage shortly after delivery.