Sentences with phrase «ros levels»

Although very intense, heavy training increases ROS levels, this is precisely what is needed for optimal recovery.

Although ROS levels increase during exercise, this is a good thing.

When ROS levels increase, such as during a high volume Mountain Dog workout, Keap1 is degraded, releasing NRF2, which then moves into the nucleus.

However, during times of disease, exercise, or environmental stress (e.g. smoking, UV or heat exposure) ROS levels can increase dramatically, which can result in significant damage to cell structures.

However, during times of disease, exercise, or environmental stress (e.g. smoking, sunlight or heat exposure) ROS levels can increase dramatically, which can result in significant damage to cell structures.

These results are in line with recently published findings showing that in APP transgenic mice (Tg2576), the pesticide paraquat which enhances ROS levels also increases Aß levels and leads to cognitive impairment [36].

Also, the skeletal muscles of BCAAem - treated mice exhibit lower levels of lipid peroxidation (an indirect index of ROS levels) than do those of untreated mice.

The anti-senescence function of p53 involves direct activation of sestrin genes, which encode proteins that regulate ROS levels and the AMPK / mTOR pathway.

This modification is of special interest to p53 - dependent anti-senescence and pro-longevity functions because genetically engineered mice with p53 serine18 mutated to alanine (p53S18A) show increased ROS levels, metabolic stress, tumor frequency, premature aging symptoms and defects in regulation of a subset of p53 target genes that include sestrins.

ROS levels, as measured by the proportion of cells that stained positive for CellROX, increased from an average of 8.1 % in cultures treated with DMSO to 78 % in cultures treated with curcumin.

Thiol - reactive electrophilic compounds often increase ROS levels in cells, as a consequence of their ability to deplete glutathione.

We observed increased TBARS (Table 1) and ROS levels in the pancreatic tissues of WNIN / Gr - Ob rats in both basal and with L - arginine induction as compared to their respective controls (Fig. 3a), which is in line with previous findings [18].

As a result, the activities of the antioxidant enzymes glutathione peroxidase and catalase were restored, ROS levels decreased, and the bacterial biofilm disintegrated in the wound — all of which resulted in the development of healthier wound tissue and led to wound healing.

«By decreasing ROS levels within a chronic wound in a diabetic mouse model, my lab was able to normalize conditions and heal the wound,» Martins - Green said.

«With the degradation of the gel, the ROS level in the tumour site can be reduced, which also helps inhibit tumour growth.»

If the stock reaches that level, a continued hold (with stop loss) would be the best strategy in light of prior peak EPS / RoE levels.

Not exact matches

Next, to decrease ROS to normal levels, the researchers applied two strong antioxidant supplements, vitamin E and N - Acetyl cysteine.

They saw that the level of ROS in this quasi-synaptic space fluctuated without any cellwide changes.

Ordinarily, these enzymes help maintain normal tissue levels of ROS.

Finally, the researchers discovered that ROS generation subsided as the iPSCs matured, and these mature stem cell colonies survive best in a cellular environment with low levels of ROS.

In the context of cancer, a high level of ROS is a major player in tumour development and growth.

Reactive oxygen species (ROS) induce cellular damages at different levels (proteins, DNA, and lipids) which increase the body susceptibility to noxious injuries with the final result to accelerate aging and decrease lifespan.

Intracellular reactive oxygen species (ROS) levels were measured for all groups as described earlier [22].

These observations suggest that ARE - regulated genes may be controlled by an intracellular ligand independent of ROS generation, electrophilic reactivity or elevation of Nrf2 levels in the cell.

Levels of ROS were measured in HepG2 cells following exposure to either HPP - 4382 or curcumin, a highly reactive electrophilic compound.

At the cellular level, p53 can either induce senescence or, of major interest here, inhibit senescence by controlling both reactive oxygen species (ROS) levels and a signaling pathway mediated by protein kinases AMPK and mammalian target of rapamycin (mTOR).

Among their work, the investigators are looking at how ROS affects gene regulatory responses in cells that are exposed to elevated glucose levels or other stimuli.

Increased cellular ROS is often accompanied by a decrease in cellular glutathione levels.

Indeed, cycles of chemotherapy that sustainably increase ROS reduce H2AX protein levels in Triple - Negative breast cancer (TNBC) patients.

As Dr. Blackwell notes, high levels of ROS molecules are associated with diabetic complications.

«It's clear that at high levels, ROS molecules can damage proteins, promoting aging and worsening disease states,» he says.

The generation of ROS during energy production increases with aging and increased inflammation levels.

When the levels of ROS in the hypothalamus are restored in the laboratory, the pancreas starts to secrete the correct levels of insulin again.

Importantly, the enhanced Aß generation could be attenuated by ROS scavenging using the antioxidant vitamin C. However, very high concentrations much above therapeutical levels were needed.

High levels of ROS could cause oxidative damage to tissue.

At normal to low levels, ROS and RNS are necessary for the immune system — they are released by innate immune cell macrophages to destroy invading pathogens, and they act as innate system messengers, warning of incoming invaders.

High levels of ROS aren't necessarily bad in all cases.

Besides promoting immunogenicity of the thyroglobulin molecule, dietary iodine can enhance levels of reactive oxygen species (ROS), which lead to expression of cell adhesion molecules (ICAM - 1) that are crucial to the early phases of thyroid follicular inflammatory responses (3).

With age, ROS - induced aberrant triggering of the insulin signaling mechanism in the postabsorptive state inhibits autophagy, preventing maintenance of plasma cysteine and intracellular glutathione levels throughout the night and early morning hours, and initiating a vicious cycle of progressively increasing oxidative stress and mitochondrial dysfunction.

Among the animal sources of traditional food, the highest levels of vitamin C were found in samples of raw beluga and narwhal mattak, boiled beluga mattak, aged narwhal mattak, fish roe, ringed seal and caribou liver, ringed seal brain and caribou kidney.

* It is a precursor to and supports tissue levels of glutathione (GSH), the principle defense within the body against reactive oxygen species (ROS) and the detoxification of drugs, metabolites and other compounds.

Increased reactive oxygen species (ROS) levels have been observed in post-mortem brain tissue from patients with neurodegenerative disorders, including [9]:

«The chronic exposure to high levels of ROS is associated with the development and / or progression of pathophysiological processes, and implicated in an increasing number of human diseases, such as cardiovascular, metabolic, inflammatory and neurogenerative diseases, cancer as well as muscle atrophy and the ageing process.»

In one study, researchers found that levels of mitochondria - destroying ROS fell by 19 % in people taking 40 mg of resveratrol daily for six weeks.

It helps creates an army of new free - radical fighters to quench the high levels of ROS free radicals that I mentioned earlier to help keep your mitochondria healthy.

-RCB- elevated sodium level within kidneys, either as a result of pathological bottleneck such as reduced number of nephrons, or simply due to heightened intake - or both - may activate pro-inflammatory cytokines and chemokines in proximal tubular cells, may cause oxidative stress by activating ROS - producing NADH oxidase enzymes, or blood vessel constriction by inhibiting kidney arginine transport and nitric oxide synthesis; elevated renal inflammation, oxidative stress and restricted blood flow all can impair the efficacy of sodium excretion, more so combined (if extensive, it can also result in post-natal reduction of nephron units)

After all, high levels of ROS have been associated with many age - dependent diseases, due to the fact that ROS are -LSB-...]

The 2009 German study used sedentary, unfit subjects, who thus would be expected to produce very high levels of ROS in response to the unfamiliar stress of exercise.

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