Mfrprd6 mice demonstrate abnormal
RPE microvilli development, a delay in outer segment development, an impaired ability to phagocytize shed OSs, and potentially, an impairment of adhesion between RPE and outer segments.
Akin to human
RPE, the cells were highly polarized with basal nuclei, apical
microvilli and adherens junctions (Fig. 2C and 2D).