The three
Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.
Not exact matches
In subsequent research, Slack
found that let - 7 controlled the amount of KRAS protein that the
ras gene KRAS produced.
We
found three Bt
genes over the entire period of colonization (up to Day 28) with significantly larger than expected TA ‐
RA and TA ‐ NEC values (q ‐ values < 0.05; Table 1); these
genes also showed significant selection during early colonization (up to Day 4).
The three
genes FOXO3, NCOA3, and TCF7L2 were
found mutated in human colorectal cancers and affected several established
Ras pathway manifestations.
As expected, we
found that dozens of
genes already known for
RA from European and Asian populations also play an important role in Arabs.
The team
found that mutations in a
gene called HLA - DRB1 are associated with
RA risk in Arab populations just as is the case with Europeans and East Asians, suggesting broad similarities in the genetic structure of
RA across ethnic groups.
This new research, conducted by scientists in Belgium and published in the journal Nature Communications,
found that in yeast, the presence of high levels of glucose (sugar) can activate a
gene called
Ras — the role of which is to regulate cell generation, both in mammals and in yeast — which is often
found in tumours.