Sentences with phrase «receptor gene methylation»

Interactions Between Oxytocin Receptor Gene Methylation and Callous - Unemotional Traits Impact Socioaffective Brain Systems in Conduct - Disordered Offenders.

Not exact matches

Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress - related disorders causality: A critical review

Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney's lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain.

This difference was caused by methylation of a gene for a stress receptor, explained Fernald, the Benjamin Scott Crocker Professor of Human Biology.

Infants with more methylation of a gene known as retinoid X receptor - α (RXRα), which codes for a protein involved in the development of fat cells and fat metabolism, were more likely to be obese at age 9.

To cope, the neurons used methylation and demethylation like a volume knob, constantly adjusting the signal strength of connected neurons by turning on or off the genes that make the signal receptors.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

It has been shown that the induction of an altered phenotype by a maternal protein restriction diet during pregnancy involves changes in DNA methylation and histone modifications in specific genes, including the glucocorticoid receptor (GR)(33 % lower; P < 0.001) and PPAR?

[PMID 26175754] DNA methylation and single nucleotide variants in the brain - derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety / depression in older women

Moreover, they have shown that, through differential patterns of DNA methylation of the promoter region and thereby differential expression of the estrogen receptor alpha gene in the medial preoptic area (MPOA) of the brain, this individual variation of early experience influences adult reproductive behaviour, suggesting a mechanism for intergenerational transmission of the pattern of maternal care [137, 138].

DNA methylation of the oxytocin receptor gene predicts neural response to ambiguous social stimuli

To compare levels of methylation of the glucocorticoid receptor (GR) gene (NR3C1) promoter between women with bulimia nervosa (BN) and women with no eating disorder.

Environmental risk, oxytocin receptor gene (OXTR) methylation and youth callous - unemotional traits: a 13 - year longitudinal study.

Methylation of the glucocorticoid receptor gene promoter in bulimic women: Associations with...

Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: A link with the severity and type of trauma

Associations among oxytocin receptor gene (OXTR) DNA methylation in adulthood, exposure to early life adversity, and childhood trajectories of anxiousness.

Maternal mental well - being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate.

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress response