Sentences with phrase «receptor avidity»

Freedman, B.D., Liu, Q.H., Somersan, S., Kotlikoff, M.I. & Punt, J.A. Receptor avidity and costimulation specify the intracellular Ca2 + signaling pattern in CD4 + CD8 + thymocytes.

Not exact matches

One unifying aspect of these methods is that we are expecting extracellular interactions to be very weak, and so we purposefully increase binding avidity when performing our receptor interaction screens experiments by oligomerising the protein probes.

By examining a number of receptor systems (see figure), the researchers demonstrated that receptor system response can be characterized as being either avidity - controlled, which depends primarily on ligand capture efficiency; consumption - controlled, where the ability to internalize surface - bound ligand is the primary control parameter; and dual - sensitive, in which both the avidity and consumption parameters are important.

Most significantly, the researchers believe that the evolution of a given receptor system can be understood in terms of its optimal location in avidity - consumption parameter space.

T Cell Receptor Signaling Can Directly Enhance the Avidity of CD28 Ligand Binding.

The longer duration of analgesia associated with SIMBADOL is likely related to a combination of dosage, metabolism and receptor affinity and avidity.