Sentences with phrase «regulation of gene expression by»

His lab is interested in the regulation of gene expression by mRNA processing in C. elegans and human cells.

Not exact matches

Results showed that BPA exposure permanently affected the uterus by decreasing regulation of gene expression.

Histones and other proteins, when modified by this process known as acetylation, play critical roles in regulation of gene expression, typically resulting in increased gene expression.

Without an adequate supply of the S - adenosyl methionine, regulation by histone methylation — and therefore correct gene expression — can not take place.

A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

Plants perform these regulations mainly by regulating nuclear gene expression and multiple intracellular signaling pathways have been shown to play a role in the genomic response of plants to stress, but the processes are not well understood.

The research that led to these findings is part of a larger effort to better understand gene regulation and expression, carried out by the GTEx Consortium, a National Institutes of Health - funded group that includes researchers from around 80 institutions founded in 2010.

Compared with the ancestral lineage, the East African cichlid genomes possess: an excess of gene duplications; alterations in regulatory, non-protein-coding elements in the genome; accelerated evolution of protein - coding elements, especially in genes for pigmentation; and other distinct features that affect gene expression, such as insertions of transposable elements and regulation by novel microRNAs.

The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation.

We found an excess of gene duplications in the East African lineage compared to tilapia and other teleosts, an abundance of non-coding element divergence, accelerated coding sequence evolution, expression divergence associated with transposable element insertions, and regulation by novel microRNAs.

This could be an indication of a controlled expression of genes responsible for calcification during daytime, as evidenced by the up - regulation of genes associated with the cartilage and bone biogenesis process.

Finally, Yingjie Guan, assistant professor (research) of orthopaedics at Brown and Lifespan, at the COBRE for Skeletal Health and Repair, talked about her detailed work on how mechanical regulation of gene expression, for instance by the micro RNA miR - 365, affects cartilage and bone health.

Transcriptome studies such as the National Institute of Health's Genotype - Tissue Expression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNAExpression (GTEx) program aim to overcome this limitation by studying gene expression levels and regulation mechanisms and their relationship with diseases, instead of only DNAexpression levels and regulation mechanisms and their relationship with diseases, instead of only DNA sequence.

These studies are unable to determine a causal relationship due to factors such as gene regulation — a genetic variant may instead contribute to altered expression levels of true causal genes, which remain undetected by a GWAS.

In this study, we also identify p21waf1 / cip1 as a target gene of DDX3, and the up - regulation of p21waf1 / cip1 expression is linked to the growth - suppressive effect exerted by DDX3 (see Fig. 2).

It was while he was working on his doctoral project, wing formation in fruit flies, that a discovery made by other investigators in the lab — of the first microRNA (a small RNA important in the regulation of gene expression) identified in the fly — captured his attention and has held it ever since.

We confirmed the role of Nrf2 in the regulation of HMOX1 gene expression by HPP - 4382 using genetic silencing of Nrf2.

To identify key molecular mediators of the ABL kinases implicated in the regulation of the ABL1 / ABL2 - dependent pathways, we analyzed the expression of individual genes for transcripts altered by loss of the ABL kinases.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

Adipose tissues from various anatomical sites are characterized by different patterns of gene expression and regulation

The Kind group studies the regulation of gene expression in single cells by developing and using novel microscopy and genomics based techniques.

If you would like to join our effort to analyze the regulation of gene expression and the mechanisms by which it can be disrupted in cancer, please contact Anthony at anthony [dot] mathelier [at] ncmm [dot] uio [dot] no.

The lack of co-expression of pluripotency markers and lineage specific markers at the protein level despite robust co-expression of transcripts of both classes of gene suggests a role for post-translational regulation of expression, perhaps by small RNAs.

«Gene therapy, or any treatment that relies on tight regulation of gene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says KarGene therapy, or any treatment that relies on tight regulation of gene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says Kargene expression, could be improved by precisely targeting molecules to the right place in the nucleus,» says Karpen.

Under the direction of Pierre Chambon (1994 - 2002), the research conducted by the teams mainly addressed the question of the regulation of gene expression.

In young animals, immunological activation drives a conserved transcriptomic switch, resulting in tightly controlled gene expression characterized by a strong up - regulation of a core activation program, coupled with a decrease in cell - to - cell variability.

Conclusion: These findings highlight innovations specifically evolved in platyhelminths presumably associated with novel mechanisms of gene expression regulation mediated by small RNA pathways that differ to what has been classically described in model organisms.

Based on the gene expression profile, we demonstrated the up - regulation of hormone sensitive lipase and enhancement of the lipolytic activity by the treatment of adipocytes with C3G or Cy.

Although scientists and laypeople alike once believed that the effects of genes on health and behavior are direct and immutable, scientists now recognize that there is substantial regulation of genetic expression by the environment, resulting in gene — environment interactions.