Sentences with phrase «retinal cell and gene»

Not exact matches

«We introduce a gene that encodes a light - sensitive protein, and we target the expression of that gene to a subset of retinal cells.»

A new gene therapy treatment has restored some sight in a handful of blind patients suffering from Leber's congenital amaurosis, a syndrome in which, because of a broken or missing gene called RPE65, retinal photoreceptor cells malfunction and eventually die.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

Dyer and his colleagues also mapped the three - dimensional organization of the retinal epigenome to discover how retinal cells package their genes in concentric regions of the cell nucleus.

In our studies, we're trying to decipher the functional significance of why the retinal cell packs some genes away and makes others more accessible.

Spark CEO Jeff Marrazzo says their more potent vector and differences in how the treatment is made, such as the company's use of a surfactant to make sure the vector doesn't stick to the vial when the surgeon injects it, may result in a higher dose of the RPE65 gene getting into retinal cells and long - lasting effects.

They have learned how to turn on and off essential genes and how to transform embryonic stem cells into retinal cells, which can be transplanted into mice to restore vision.

In research published this week in the Journal of Neuroscience, University at Buffalo scientists and colleagues focused on a particular protein, called a transcription factor, that regulates gene activity necessary for the development of one type of retinal neuron, the horizontal cells.

In recent years, scientists have grown new retinal cells from stem cells and shown progress in developing an effective gene therapy.

Cultured mouse, monkey, and human pluripotent cells can be driven down a retinal lineage as determined by the expression of marker genes, including the EFTFs [2]--[4].

Farkas et al. [29] and Ivanov et al. [30] reported on gene expression profiling in purified populations of rat retinal ganglion cells.

Importantly, 25 of the 115 transcripts, shared by EFTF - expressing pluripotent cells and the EF, encode for 15 genes that are both expressed in retinal stem / progenitor cells and required for normal eye formation in frogs, fish, mice, or humans (Figure 1C; Table S1).

However, when forced to express the eye field transcription factor (EFTF) genes, the cells differentiate into all seven retinal cell classes and eventually organize themselves into a functioning eye that can detect light and guide tadpoles in a vision - based behavior.

Dominic Eberle (Ader, TUD)-- «Cell transplantation and gene therapy approaches for the treatment of retinal degenerative disorders» (2012)

Many of the most promising approaches fall into four categories: the retinal prosthetic, gene therapy, stem cell treatments, and a technique that uses optogenetics, a way to engineer nerves to fire in response to bursts of light.

Some researchers seek gene therapies that might act more broadly on retinal cells, perhaps by using genes that produce proteins supporting the growth and health of nerve cells, which could be delivered before significant vision loss occurs.

The treatment could help people who have a fault in a gene called RPE65, which causes problems in the retinal pigment epithelium (RPE), a thin layer of cells that support and nourish photoreceptors.

Dr. Otteson studied how retinal ganglion cells turn on and off the genes that regulate the normal patterns of connections during optic nerve development.

Our objective is to determine whether this mutation is involved in AMD by (1) understanding the functional consequences of this genomic variation on expression of COL8A1 and / or its neighbor genes, and (2) investigating photoreceptors and RPE cell survival, retinal and choroidal angiogenesis, structure integrity of the choroid / Bruch's membrane, and the quality of the vision, in organisms with the COL8A1 mutation.

Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model Soto, I., Oglesby, E., Buckingham, B.P., Son, J.L., Roberson, E.D., Steele, M.R., Inman, D.M., Vetter, M.L., Horner, P.J. & Marsh - Armstrong, N. (2008) Journal of Neuroscience, 28:548 - 61.