Sentences with phrase «rodent models for»

The results were obtained from mice and human stem cells in cultivated brain tissue, and from a series of rodent models for human neurodegenerative diseases and acute brain injuries.

Not exact matches

Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models.

«The project's goal is to accelerate the development of technologies for mapping the brain's circuitry in animal models, specifically in the marmoset monkey, whose neural circuits are much closer to human compared with rodent models, and to connect the results to the diagnosis and treatment of human neurological disorders and mental illness.»

Harding also argues that because rodent studies suggest that these animals do lose neurons to alcohol, they may be unreliable models for the human hippocampus.

«Rapamycin treatment prevents crippling abnormal bone formation after severe limb injuries: Significant benefits seen after treatment with FDA - approved drug in rodent model of blast - related limb injury hold promise for first effective treatment to prevent trauma - induced heterotopic ossification (HO) formation.»

For the JCI study, the team applied the radiotracer to monitor olfactory sensory neuron population dynamics in a rodent model, using PET to measure its uptake across the animals» lifespan, including during age - related neurodegeneration.

Historically, mice have been the rodents of choice for autism research, partly because there are so many models representing a broad range of autism - relevant genetic mutations, and partly because they're small and relatively cheap.

«The work clearly shows that, despite their size, small rodents play a much larger role in seed dispersal for some tree species than previously recognized,» says Joshua Plotkin, a population biologist at the University of Pennsylvania who mathematically models evolutionary and ecological questions.

Pandey performed the experiments using an animal model during which rodents were exposed to alcohol for a long period of time.

This webinar will discuss the promise CRISPR / Cas9 has for rodent studies along with strategies for developing better models to understand and treat human disease.

«Importantly we contend that using juvenile rodent inactivity models will continue to provide a powerful clinical translational tool that can be used for primordial prevention of human childhood obesity.»

General Product Information Obesity - High Fat Diets for Diet - Induced Obesity Models Metabolic Syndrome - Diet - Induced Metabolic Syndrome in Rodent Models Diabetes - High Fructose / Sucrose Diets for inducing Hypertriglyceridemia and Insulin Resistance in Rodents Atherosclerosis - Diet - Induced Atherosclerosis / Hypercholesterolemia in Rodent Models Hypertension - Phenotypic Expression of Hypertension in Rodent Models through Dietary Manipulation NAFLD (Non-alcoholic Fatty Liver Disease) Cancer - Creating a Clean Background for Oncology Research Test Compounds / Kaolin Pellets Diet and Immunology Focus: Arsenic in Grain - Based Laboratory Animal Diets and Effects on the Rodent Toxicological Phenotype Focus: The Importance of a Proper Control Diet

Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

Review of «Intrastriatal Transplantation of Adenovirus - Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington's Disease» from Stem Cell Translational Medicine by Stuart P. Atkinson.

To carry out pre-clinical testing of stem cell - derived mesDA and striatal GABAergic progenitors in rodent models of PD and HD with the goal to generate efficient and safe candidate cells for clinical use;

We will leverage state - of - the - art bioinformatic and biological approaches for investigating how these factors interact in combination to regulate axon growth during RGC development and test the potential of such factors for regenerating RGC axons in a rodent model of optic nerve injury.

Animal rodent models are useful tools for studying obesity as they will readily gain weight when fed high - fat diets.

Use of genetically modified rodents for gene validation - New approaches for time saving and models of higher relevancy

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

Partners of INFRAFRONTIER, the European Research Infrastructure for phenotyping and archiving of model mammalian genomes, offer an excellent training opportunity in using innovative technology for rodent body temperature telemetry.

But certain aspects of this rodent's biology — and responses to stress — are enough like a human's for it to «model» what might happen in people.

Thursday 19 April 2018 8:30 — 9:15 Marie - Christine Birling (The Institut Clinique de la Souris, Strasbourg, France) CRISPR for the generation of innovative rodent models (the lecture takes place in yellow and blue seminar room of BIOCEV)

Since the presence of phytoestrogen containing sources (i.e. soy protein and isolated isoflavones) has been found to influence atherosclerosis and lipoprotein metabolism in various rodent models (7 - 13), the use of purified Western - type diets provides a clean «reagent» for inducing this disease.

«Rodents as models for biomedical research.»

In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamanders are able to completely regenerate heart tissue, whole limbs and many other tissues following injury, at any life stage.

Nippostrongylus brasiliensis, a nematode parasite of rodents, has a parasitic life cycle that is an extremely useful model for the study of human hookworm infection, particularly in regards to the induced immune response.

This review will highlight commonly used dietary factors able to influence LDL - C and atherosclerosis in various rodent models, as well as some of the potential benefits and drawbacks associated with using these models for disease induction.

Consequently, alternate - day fasting is a widely used model for studying the effects of calorie restriction in rodent species (15).

Cats and dogs that develop diseases like cancer naturally are often better models for human disease than lab rodents are, which is why more and more drug...

The rodent models have shown that microglial cells, which normally provide an immune defense for the central nervous system, become abnormally activated in ALS to produce neurotoxicity.

Therapeutics targeting microglia have slowed disease progression in rodent models, but have failed to translate into effective therapy for ALS patients.

We provide evidence for a causal link between the early caregiving environment and stress response system reactivity in humans with effects that differ markedly from those observed in rodent models.

Stress paradigms in rodent models have been associated with elevated anxiety and contrasting alterations in neuronal morphology in the hippocampus and amygdala, with dendritic atrophy observed in the hippocampus and increased dendritic arborization in the amygdala.12, 13 Developing rodents deprived of maternal nurturance show decreased hippocampal volume and altered stress reactivity.14 An epigenetic mechanism for this effect has been elaborated.15 Importantly, controlled trials that have randomized institutionalized toddlers to early therapeutic foster care vs institutionalization have documented the deleterious effects of early relative deprivation on cognitive outcomes.16