Sentences with phrase «sercaii isoform»

In the current study, deploying TFPI and an isoform of tenascin C, TNC - FN IIIC, with CA 19 - 9 improved performance discriminating stage I and II disease from healthy or benign disease controls.

An isoform of amphiphysin 2 concentrated at T - tubules induced tubular plasma membrane invaginations when expressed in nonmuscle cells.

The African American mRNA variants encode protein isoforms that make a tumor more aggressive, whereas the protein isoforms generated in European Americans appear to make the tumor less aggressive.

«We found that the protein isoforms expressed in African Americans with prostate cancer do not always respond to targeted therapies, whereas these drugs were found to be effective in European Americans with prostate cancer and do end up killing off the cancer,» said Lee.

Amphiphysin isoforms have a putative role in membrane deformation at endocytic sites.

These varying combinations lead to the generation of slightly different proteins known as isoforms, which can end up functioning differently from each other.

Oocytes contain a high concentration of an oocyte - specific isoform of p63 which plays a key role as a quality control factor in causing infertility.

Carstens hopes that further study of Esrp1 and Esrp2, and in particular the proteins whose splice isoforms they control, will uncover useful clues about how these defects arise and how they might be remedied.

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

Previous testing relied on «isoform» ratios: Natural hGH comes in two different weights, or isoforms, but synthetic hGH comes in only one weight.

This region is present in Numb isoforms 1 and 2 but excluded from isoforms 3 and 4.

In mice lacking the NDST1 gene, and therefore the NDST1 enzyme, nature substitutes with an NDST1 isoform (NDST2, NDST3, and NDST4), but the results — like substitutions in cooking — are noticeable.

We are one of the most referenced companies in the industry and continue to collaborate to develop products such as isoform - specific AKT antibodies, green fluorescent protein (GFP) and red fluorescent protein (RFP) antibodies, and fluorochrome - conjugated secondary antibodies.

Its two isoforms — MAO - A and MAO - B — work together to help maintain the balance of neurotransmitters in the brain.

The roadmap outlines future research directions toward the goal of enhancing human radioresistance, including upregulation of endogenous repair and radioprotective mechanisms, possible leeways into gene therapy in order to enhance radioresistance via the translation of exogenous and engineered DNA repair and radioprotective mechanisms, the substitution of organic molecules with fortified isoforms, the coordination of regenerative and ablative technologies, and methods of slowing metabolic activity while preserving cognitive function.

«Last year, we reported analogous findings with microRNA isoforms.

Pancreatic cyst fluid is tested for a biomarker, a specific isoform of vascular endothelial growth factor A, or VEGF - A.

Called isoforms, these proteins are produced when only part of the gene's code is read.

«Our results support that gene expression responses of PGC - 1α isoforms may have an important role in exercise - induced muscle adaptations,» the researchers stated.

The researchers found that both endurance and resistance exercises produced isoforms PGC - 1α exon 1b, PGC - 1α exon 1b» and truncated PGC - 1α, while only endurance exercise produced PGC - 1α exon 1a isoform.

Consequently, this RNA isoform is not transported to the dendrites for translation.

Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity

The isoforms beta ARK - 2 and beta - arrestin - 2 are highly enriched in and localized to the dendritic knobs and cilia of the olfactory receptor neurons where the initial events of olfactory signal transduction occur.

When the PP2A catalytic C subunit associates with the A and B subunits several protein isoforms, namely holoenzymes, are produced with distinct activity and substrate specificity.

In the context of the current study, TRAF6's regulation of RNA isoform expression is important to the function of hematopoietic cells and reveals another dimension to how cells respond to infection, Starczynkowski said.

The reason it's called MGF — mechano growth factor — is that the mRNA [messenger RNA] of isoform 4 is elevated when mechanical stress is applied to muscle tissue.

M.T.: The closest way to describe it is human IGF - 1 isoform 4.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

While the two actin isoforms differ by only four amino acids, their mRNA coding sequences differ by almost 13 percent because of «silent» nucleotide differences that nevertheless encode the same amino acids.

At SAGE KE (http://www.sciencemag.org/sciext/drugdisc/#insageke), Raber describes the role of isoform - dependent interactions of apoE with androgens and androgen receptors in the progression of Alzheimer's disease.

These changes in mitochondria - and calcium - related markers occurred without any changes in the myosin heavy chain isoform composition of these muscles, as assessed by quantitative PCR (qPCR)(data not shown).

In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.

Mice that lack either IL - 15 or IL - 15Rα have unique phenotypes (14, 15, 27, 28), and multiple isoforms of IL - 15Rα exist that can either potentiate or inhibit the effects of IL - 15 (29 — 33).

«Secreted αKlotho isoform protects against age - dependent memory deficits.»

The muscles from IL - 15Rα — KO mice had a greater relative expression of the SERCAII isoform and lower mRNA and protein levels of calsequestrin, both characteristic of slow muscles (52).

Adding to the documented complexity of IL - 15 — related activity, multiple isoforms and splice variants of IL - 15Rα exist as both membrane - bound and soluble forms that can either inhibit or potentiate IL - 15 biological activity (29 — 33).

Although the current study demonstrates that loss of IL - 15Rα promotes this phenotype, future studies are needed to determine the roles of specific IL - 15Rα isoforms in muscle, as well as the associations of additional IL15RA polymorphisms in muscle phenotypes in humans.

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes.

To test this, we created translational reporter transgenes regulated by the putative endogenous promoter expressing isoform b and lines in which the genomic locus was tagged by an in - frame C - terminal GFP cassette.

(Mixture - of - Isoforms) for isoform quantitation using RNA - Seq is a probabilistic framework that quantitates the expression level of alternatively spliced genes from RNA - Seq data, and identifies differentially regulated isoforms or exons across samples.

Since using the WormBase name of W01A8.1 (MDT - 28) would be misleading, the gene is referred here by the cosmid name W01A8.1, which gives rise to at least three protein isoforms designated W01A8.1 a, W01A8.1 b, and W01A8.1 c from at least seven different transcripts (W01A8.1 a. 1, W01A8.1 a. 2, W01A8.1 b. 1, W01A8.1 b. 2, W01A8.1 b. 3, W01A8.1 c. 1, W01A8.1 c. 2).

This technology is based on differential expression of key gene transcript variants (isoform - level gene expression) and was originally tested on a vast collection of glioblastoma samples made available by the University of Pennsylvania.

SAM can be combined with a human genome - wide library to activate all 23,430 known coding isoforms from the RefSeq database.

All these functions will have to be investigated in the isoforms of W01A8.1 in the future.

In vitro, transforming human brain neuroglioma or Chinese hamster ovary cells with an amyloid - β isoform resulted in better survival following a yeast infection.

According to the C. elegans nomenclature, we suggest to rename W01A8.1 as Cel - plin - 1 (isoform a, b, and c) and proteins Cel - PLIN - 1 (isoform a, b, and c).

However, its extreme length (> 13kb), number of exons (> 50) and high level of alternative splicing means CACNA1C isoform structure and expression is poorly understood, making it difficult to identify which gene isoforms confer disease risk and where they are expressed.

We observe that protein isoforms expressed from W01A8.1 are cytoplasmic proteins, residing predominantly on membranous structures of enterocytes and epidermal cells that have the characteristics of lipid droplets.

There are two ADAR1 isoforms, an interferon inducible full length p150 and a shorter N - terminus truncated p110.

Schemes for isoforms expressed from W01A8.1 gene and preparation of GFP tagged transgenes are given in Figs.