Nusinersen and similar compounds being developed for spinal muscular atrophy focus on increasing or making more of the SMN
gene product that gets converted into usable protein.
Then, researchers then sought a way to increase SMA
gene product levels, the messenger RNAs (mRNAs), and thus protein levels by silencing or removing the SMN lnc - RNA.
Since
the gene product of YME1 is a potent suppressor of mitochondrial DNA migration into the genome of the yeast Saccharomyces cerevisiae, Tiwari and Singh investigated the human homologue of the YME1 gene, called YME1L1.
When human YME1L1 was introduced into yeast with the mutated YME1, the human
gene product partially rescued the YME1 mutation, preventing migration of mitochondrial DNA into the nucleus.
Exposure to bright light at night resets circadian rhythms by acutely changing the amount of some clock -
gene products.
It is likely that previously uncharacterized
gene products with intriguing effects on behavior will be discovered within these networks.
The 4,000 missing
gene products needed for bacterial growth can be supplied by wet, warm human tissue.
Human cells infected by the viruses produced
the gene products, giving T cells an advance exposure to them.
Because of a chromosomal abnormality, this gene sometimes fuses with another gene and forms a hybrid, or a gene fusion, resulting in
a gene product with an entirely different function, causing cancers.
In this way, the team identified a new small protein, growth inhibitor
gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells.
«In addition to the potential of these genes and
gene products to help us design new drugs, they could also serve as biomarkers for accurate diagnosis,» she says.
«The genes which these miRNAs regulate also had increased levels, indicating that these gene expression, indicating that
these gene products were likely targeted for storage and for possible future use within the brain cell, rather than for destruction.
As a result, patents on human
gene products allowed in some European countries may be banned in others.
Recent work indicates that individual T lymphocytes possess receptors that interact with both thymus - dependent antigens and MHC
gene products, either independently or as associated structures.
Those gene products are usually proteins and perform vital functions in the body.
In his talk, Wieland Huttner, a molecular cell biologist and developmental neurobiologist at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI - CBG) in Dresden, Germany, explained how his team searched databases for proteins and other
gene products expressed in the human brain in these earliest phases of development.
The signal induces the expression of many innate immune and antiviral genes and the production of antiviral
gene products, pro-inflammatory cytokines, chemokines and interferons.
The problem chiefly involves antibodies, a class of proteins scientists have used for generations for everything from quantifying receptor expression to purifying critical
gene products.
Many breast cancers are marked by a lack of HOXA5 protein,
a gene product known to control cell differentiation and death, and lower levels of the protein correspond to poorer outcomes for patients.
Markowitz and University of Kentucky Professor Hsin - Hsiung Tai earlier had demonstrated that
a gene product found in all humans, 15 - hydroxyprostaglandin dehydrogenase (15 - PGDH), degrades and reduces the amount of PGE2 in the body.
They found that minor allele carriers had less IL - 28B
gene product activation stronger antibody immune response to influenza vaccination.
Kuruvilla's lab group — which has been studying the peripheral nervous system for years — found that abundance of a particular
gene product in Down syndrome puts a brake on NGF's actions in fostering nerve development.
Similarly, the particular
gene products that may result from cap - independent translation have yet to be identified and characterized.
Melton and colleagues are now doing large scale screening with microarrays to track gene activity as cells develop and discover
gene products that move cells along the proper paths.
They also suggest that «this strategy may facilitate control of... viruses uncharacterized at the molecular level, regardless of their genome type or variations in
gene products.»
It will potentially eliminate the need to sequence around a newly discovered disease SNP to find the variant that actually alters
the gene product, says NHGRI Director Francis Collins.
«We may have discovered a major step toward developing a «dream tool» for remotely controlling neural circuits, by manipulating specific cells using engineered
gene products that respond to magnets,» said Ali Deniz Güler, a UVA biology professor who led the study in his neuroscience lab.
We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1
gene product P - glycoprotein (P - gp), nonetheless results in P - gp with altered drug and inhibitor interactions.
Very soon after fertilization, the control of embryonic development shifts from pre-existing maternal
gene products to the products of genes encoded by the early embryo (or zygote).
They modernized the factory by updating the carboxysome, a particularly complex BMC that requires a series of protein - protein interactions involving at least six
gene products to form a metabolic core that takes CO2 out of the atmosphere and converts it into sugar.
The new protein replaces four
gene products, yet still supports photosynthesis.
«Type III» cells of rat taste buds: Immunohistochemical and ultrastructural studies of neuron - specific enolase, protein
gene product 9.5, and serotonin
The double strand break then can be repaired by error - prone non-homologous end joining (NHEJ) often introducing insertions and deletions leading to a non-functional
gene product when this break is placed within the coding region of the targeted gene [27].
These results suggest that by using the correct combination of
gene products, it may be possible to reprogram more readily available pluripotent cell types to a multipotent retinal cell lineage useful in healing damaged or diseased retinas.
FunCoup is a database of functional couplings, or functional associations, between genes and
gene products.
Members of a family that includes the apoptosis regulator APAF1 (apoptotic - protease - activating factor 1), mammalian NOD - LRR proteins (also known as NACHT - LRR proteins or CATERPILLERs) and plant disease - resistance
gene products.
Moreover, the proapoptotic
gene products BBC3 / Puma and BCL2L11 / Bim were downregulated in mesenchymal cells, possibly contributing further to their enhanced survival.
Evaluation and validation of candidate
gene products entail elucidation of their functional networks and mechanisms of action.
In female mammals, one of the two X chromosomes is transcriptionally silenced during early development to compensate for the double «dose» of X-linked
gene products in females -LSB-...]
Some other
gene products for treatment of CLI have failed in the late phases of clinical trials (for example,
Since then, so - called Omics technologies have flourished, allowing researchers, for example, to observe and quantify thousands of
gene products in a single tissue sample.
The UL144
gene product of human cytomegalovirus activates NFkappaB via a TRAF6 - dependent mechanism.
If
a gene product isn't approved for humans, shipping it is a felony, and the shipping party can be fined and imprisoned, says Mehlman.
By comparing the effects of multiple sequences, you can determine the extent of off target effects and infer the true biological effect of
a gene product.
No other HIV
gene products are expressed.
Additionally, the drug was shown to inhibit the TRAF2 - and NCK - interacting kinase (TNIK), a regulatory component of the β - catenin and T - cell factor - 4 (TCF - 4) transcriptional complex downstream of the adenomatous polyposis coli (APC)
gene product in colon cancer [30].
Some other
gene products for treatment of CLI have failed in the late phases of clinical trials (for example, Sanofi's FGF - based gene product).
The sequences of small interfering RNA (siRNA) targeting the human mTOR, AKT1, and 4E - BP1
gene products were purchased from Ambion, Inc. (Austin, TX) and were as follows: mTOR sense GGAGUCUACUCGCUUCUAUTT and antisense AUAGAAGCGAGUAGACUCCTC, AKT1 sense GGGCACUUUCGGCAAGGUGTT and antisense CACCUUGCCGAAAGUGCCCTT, and 4E - BP1 sense GGUACCAGGAUCAUCUAUGTT and antisense CAUAGAUGAUCCUGGUACCTC.
RNA editing, which can alter
gene products without making changes to the genome, has profound potential as a tool for both research and disease treatment.
Plasmid replication is controlled by
gene products encoded in the plasmid itself.