Sentences with phrase «snf complex»
The SWI / SNF complex is polymorphic, meaning that the complex can assume different forms through various combinations of individual subunits.
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In the absence of ARID1A, the essential activity of the SWI / SNF complex is provided by a similar protein, ARID1B.
Hargreaves brings her knowledge of biochemistry and epigenetic regulation to investigate a subunit of the SWI / SNF complex called ARID1A, which is mutated in many solid tumors, such as in ovarian, bladder and colorectal cancers.
Diana Hargreaves studies a particular epigenetic regulator, the SWI / SNF complex, which uses energy to unpack and unwind DNA from structural proteins to alter DNA accessibility and in turn, gene transcription.
Not exact matches
In healthy cells, Arid1b is part of a bigger complex (called SWI / SNF) that regulates the activity of hundreds of genes.
The collection of proteins, called a chromatin remodeling complex, is known as SWI / SNF; its components are encoded by different genes, among them ARID2, PBRM1, and BRD7.
That gene encodes a protein called BAF 180, which is a subunit of the PBAF subtype of the SWI / SNF chromatin remodeling complex.
The SMARCA4 encodes a catalytic ATPase subunit of the SWI / SNF chromatin remodeling complex.
The study published in Molecular Cell is entitled, «The Short Isoform of BRD4 Promotes HIV - 1 Latency by Engaging Repressive SWI / SNF Chromatin Remodeling Complexes.»
Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X. (2015) Regulation of Mec1 kinase activity by the SWI / SNF chromatin remodeling complex.
The highly homologous bromodomain containing protein 7 (BRD7) is a component of the SWI / SNF polybromo - associated BAF (PBAF) complex and has been proposed as a tumor suppressor [2].
The bromodomain containing protein 9 (BRD9) has been reported as a component of the switch / sucrose non-fermentable (SWI / SNF) brahma - related gene 1 - associated factor (BAF) complex, which plays a key role in chromatin remodelling and transcription control [1] although the precise biological role is unknown.
a. Mechanism - guided therapeutic strategies for genetic alterations that affect the SWI / SNF chromatin remodeling complex in epithelial ovarian cancer (such as ARID1A mutation in clear cell and endometrioid subtypes of ovarian cancer, and CARM1 amplification / overexpression in high - grade serous ovarian cancer).
The Zhang lab will pursue these issues in the coming years by focusing on the epigenetic SWItch / Sucrose Non-Fermentable (SWI / SNF) and Polycomb repressive complex 2 (PRC2) complexes as proof of principles in the context of ovarian cancer.