We continue to investigate the remarkable concurrent loss of both catalytic ATPase SWI /
SNF subunits to better understand this disease pathogenesis.
BRD7, a novel PBAF - specific SWI /
SNF subunit, is required for target gene activation and repression in embryonic stem cells.
Not exact matches
That gene encodes a protein called BAF 180, which is a
subunit of the PBAF subtype of the SWI /
SNF chromatin remodeling complex.
The SMARCA4 encodes a catalytic ATPase
subunit of the SWI /
SNF chromatin remodeling complex.
Hargreaves brings her knowledge of biochemistry and epigenetic regulation to investigate a
subunit of the SWI /
SNF complex called ARID1A, which is mutated in many solid tumors, such as in ovarian, bladder and colorectal cancers.
The SWI /
SNF complex is polymorphic, meaning that the complex can assume different forms through various combinations of individual
subunits.