Sentences with phrase «snps in»

The SNPs were then reduced in number according to inclusion limitations of the Sequenom MassARRAY and the exclusion of SNPs in 100 % linkage disequilibrium.

Vaysse and colleagues [32] identified 44 genomic regions among 49 pure breeds that had undergone intense selection and 22 blocks of SNPs in certain breeds that extended over one million bases.

As the gold standard for all four samples we used SNPs found by Affymetrix SNP6 arrays as an independent and well - established SNP calling technology (see Figure S10 and Figure S11 for an overview on the distribution of array SNPs in different regions of the genome).

Distribution of Affymetrix SNP6 array SNPs in genomic elements analyzed.

The BART cluster 2 miRNA region is classified into three major variants through SNPs in the pri - miRNA outside of the mature miRNA sequences.

Information was extracted from a recent meta - analysis of five genome - wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed.

Based on the proportions of SNP variants in the human population as estimated from a population - level mitochondrial database (mtDB)[50], the probability of sharing all 6 SNPs in common between VP42 and LNCaP by random chance alone is estimated at less than 0.00146 %.

Both of these cell line - associated XMRV genomes were found to exhibit a lower degree of intra-strain variation than previously reported for XMRV from 22Rv1 cells [20], with only 19 SNPs detected in the 22Rv1 - associated XMRV genome at the 3 % frequency cutoff by deep sequencing, and only 25 SNPs in the LNCaP - associated genome (Fig. 7A; Table S1).

To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal - associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13).

Shared SNPs in XMRV genomes corresponding to 3 XMRV - positive prostate cancer samples (VP35, VP42, VP62) and LNCaP (z - axis) at a frequency cutoff of 0.5 % are plotted on the graph, with key SNPs highlighted in red.

Although there is complex regulation across the CYP4F gene cluster, the opposing effects between the two SNPs in the CYP4F gene cluster appear to compensate for each other and their effect on warfarin dose requirement is unlikely to be clinically significant.

In this session we show that a range of approaches, including fine - mapping with very large sample sizes (which separate SNPs in high LD), or samples from multiple ethnicities (which have different LD patterns) can often identify one, or only a few, likely causal variants.

We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case - control study and an independent quantitative trait (QT) cohort in the United Kingdom.

SNPs in the 22Rv1 - Associated XMRV Genome and Comparison to the Prostate Cancer and LNCaP - Associated XMRV Genomes.

Functional annotations of the SNPs and SNPs in LD that are associated with insomnia complaints.

WAVE designed ASOs that target two SNPs in the HTT gene, which is why they're launching two separate clinical trials.

The presence of these SNPs in the ancient horses implies that selection for these traits did not occur on de novo mutations but on existing variation, which was either contributed to the domesticated stock by the ancient population through admixture or was cosegregating in both the ancestors of the ancient horses and the ancestors of the domesticated horses after their split.

Enrichment of carotenoid accumulation - associated SNPs in the Argopecten irradians draft genome

The scientists found 108 SNPs in every member of this species that had a yellow band on its hind wings.

In this study, deCODE used its population - wide genealogy database and proprietary statistical tools to determine the parent of origin of a number of SNPs in some 40,000 Icelandic participants in the company's gene discovery programs.

This was a two - part project: first, we used shotgun sequencing data to identify SNPs in a few recombinant inbred lines (RILs).

Three nonsynonymous SNPs in the hemochromatosis gene (HFE) are genotyped, and I'm heterozygous for one of them.

Although no association between mtDNA SNPs and ME / CFS vs. healthy status was observed, haplogroups J, U and H as well as eight SNPs in ME / CFS cases were significantly associated with individual symptoms, symptom clusters, or symptom severity.

On average, there were 23.2 ± 11.3 SNPs in cases and 25.8 ± 12.4 in controls relative to the Cambridge reference sequence [31].

SNPs in the human IL15 and IL15RA genes have been associated with muscle phenotypes (16), muscle responses to resistance training (17), metabolic syndrome (16), and obesity (18 — 20), providing additional rationale to support a role for these molecules in muscle.

However, this was an exploratory analysis, and additional SNPs in the IL15 and IL15RA genes and additional cohorts of athletes should be screened to further define the association between genotype and certain types of athletic performance; these analyses are currently being pursued.

SNPs in the human IL15 and IL15RA genes have been associated with responses of skeletal muscle to resistance training (17), baseline measures of skeletal muscle and bone (16), and markers of the metabolic syndrome (16), suggesting a role for these genes in skeletal muscle.

They found CAD - related SNPs in or near genes governing such functions as stickiness of cells, coagulation and inflammation, and the differentiation of smooth muscle cells.

In their paper, Daley and colleagues report that the SNPs in the Korean cell line do indeed match toward the center of the chromosomes, similar to five parthenogenetic mouse cell lines that the team created for comparison.

The sequence is an on - switch for a protein known as KIT ligand (KITLG); three previous studies have linked SNPs in this region with testicular cancer.

In the second case, the system has some chance of returning not the top - scoring SNPs in a given region, but several of the top - scoring SNPs and maybe one or two lower - scoring ones.

In the other, the user asks for a list of the SNPs in a particular region of the genome that correlate best with a particular disease.

Next, the researchers developed a genetic model comprising 150 SNPs in order to compute the predisposition of an individual toward EL.

The alleged fathers still matched the fetuses, but the profiles differed from those provided by the Canadian lab for five SNPs in one case, and seven in the other.

Labour's Scottish presence was effectively wiped out by the SNP in the 2015 general election, and pressure is on Dugdale to steer the party to a second place finish at the very least.

Labour would need an agreement with the SNP in addition to a coalition with the Lib Dems, while the Tories would need to group together several smaller parties, probably including the DUP.

(Of course, a Tory - led government could be useful to the SNP in some Scottish elections, but surely not having the responsibility for creating one).

He defended the coalition's legitimacy by pointing out that the votes received by the Conservatives and Liberal Democrats were higher than the number cast for the SNP in the Scottish parliament regional list.

On the issue of independence - and here this is obviously more interesting - Rupert Murdoch can't seem to remember why he backed the SNP in 2007, but remained neutral on the issue of independence.

Indeed, as figure 2 shows, pro-independence voters were almost as united in their support for the SNP in Westminster in 2010, when they won only 20 per cent of the vote, as they are now.

Figure 1 confirms that the proportion of Scots intending to vote for the SNP in the General Election has closely tracked support for independence throughout the last Parliament.

Dugdale had some cause to celebrate in June when Scottish Labour won back six of the Westminster seats it had lost to the SNP in 2015 but even her dearest friend wouldn't argue that she had saved the party.

Sturgeon and the man who will lead the SNP in parliament after May, Alex Salmond, may have lost a battle last September.

It was only in the run - up to the ultimately failed referendum in 2014 that support for both the SNP in the House of Commons and their raison d'etre of independence soared to the crucial 50 per cent mark.

Finally, Labour has been utterly wiped away by the tide of the SNP in Scotland.

But there were local elections in the offing the following May in which the party was due to defend what, by what at that point at least, appeared to be the high watermark of having been neck and neck with the SNP in the 2012 local elections.

This week's general election focus group report comes from two Scottish seats which fell to the SNP in 2015 but could be competitive on 8 June: Edinburgh South West, and Aberdeen South.

We were witnessing the beginnings of a party being hollowed out and of a deepening disconnection between Labour MPs and their core supporters, which, in time, would empower the SNP in Scotland and create an opportunity for Ukip in England.

Conservative, Labour, Liberal Democrat and UKIP in Great Britain, including SNP in Scotland and Plaid Cymru in Wales.

Andrew Marr tells BBC it appeared, given the support for UKIP and the Tories in England, and for the SNP in Scotland, that England was moving further to the right, and Scotland to the left.