Sentences with phrase «spn hyperexcitability»

The UCI team also uncovered that during seizures, the M - current is suppressed, which contributes to neuronal hyperexcitability.

Previous research has shown that people with cWAD can be more sensitive to pain, through an effect called central hyperexcitability.

Mutations that detrimentally affect the function of neuronal KV7 channels cause hyperexcitability syndromes such as benign familial neonatal seizures, early onset epileptic encephalopathy, and peripheral nerve hyperexcitability.

However, detailed understanding of the molecular basis for the role of neuronal KV7 channels in hyperexcitability syndromes has been lacking.

The team found the same hyperexcitability in the lymphocyte - derived neurons, validating their earlier results.

The team found that maintaining some people's neurons in a lithium - infused medium calmed this hyperexcitability.

It fits with previous research that shows mGluR5 is important for hyperexcitability, but in a different way than we had thought.»

In the absence of vitamin D, dietary calcium is not properly absorbed, resulting in hypocalcemia, leading to skeletal and dental deformities and neuromuscular symptoms, e.g. hyperexcitability.

Gage and Mertens next plan to follow the affected cells for longer periods of time to see whether the hyperexcitability they measured is only an initial manic stage of the neurons» lives or is long - lasting.

If a new drug, for instance, reverses the hyperexcitability at the cellular level, it would likely treat bipolar disorder in patients.

«If hyperexcitability is the brain network basis for these symptoms, then reducing neuronal excitability with certain drugs that modulate inhibition could be of therapeutic value in these devastating neurodevelopmental disorders.»

«Essentially, they cause acetylcholine to build up in the brain, causing hyperexcitability of neurons as well as the death of some neurons, which leads to inflammation in the brain,» said Ashok K. Shetty, PhD, a professor in the Department of Molecular and Cellular Medicine at the Texas A&M College of Medicine, associate director of the Institute for Regenerative Medicine, research career scientist at the Olin E. Teague Veterans Medical Center, Central Texas Veterans Health Care System and senior author of the paper.

In epilepsy, spermine levels decrease, causing hyperexcitability.

Using whole - cell path clamp, both dSPNs and iSPNs from Q175 6 - month old mice showed elevated membrane resistance and reduced rheobase current, consistent with previous reports of SPN hyperexcitability in mouse models of HD.

That, Goel said, mirrors the hyperexcitability seen in some individuals with the syndrome.

Hyperexcitability as a result of this imbalance has been hypothesized to contribute to poorly functionally differentiated and inherently unstable cortex in autism (Rubenstein and Merzenich, 2003).

Barry G et al. (2017) The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states.

66/4: 15 Hyperexcitability of neurons and cardiomyocytes in a mouse model of SCN8A epileptic encephalopathy.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

Working with motor neurons derived from ALS patients and healthy controls, Dr. Wainger performed fundamental electrophysiological characterization and identified motor neuron hyperexcitability in ALS patient - derived motor neurons (Wainger et al., 2014).

We see clinical signs varying from vomiting, diarrhea (with secondary pancreatitis in severe causes), to neurologic signs which include stumbling gait, weakness or hyperexcitability, seizures to coma, and occasionally cardiac arrhythmias.

Mild symptoms range from lethargy and gastrointestinal upset to severe side effects that include hyperexcitability, racing heart, abnormal behavior, sedation, or seizures.

AMANTADINE This drug acts to modulate the pain response by antagonizing the N - methyl - d - aspartate (NMDA) receptor and the role they play in central neuronal hyperexcitability (wind up).

Other clinical signs may include fever, weakness or paralysis of hind limbs, impaired vision, ataxia, aimless wandering, walking in circles, hyperexcitability or coma.7 If horse owners notice signs or symptoms of WNV infection in their horses, they should contact a veterinarian immediately, especially if horses are exhibiting neurological signs.

If you suspect that your dog has gotten into candy or notice symptoms like vomiting, diarrhea, weakness, lethargy, hyperexcitability, or collapse, call a veterinarian immediately.

Dogs can develop vomiting, diarrhea, and hyperexcitability when they ingest around 9 mg of methylxanthines per pound of body weight.

Allowing early intervention for high - risk puppies (ie, puppies removed from the litter before 8 weeks of age; that have increased fear, anxiety, and / or hyperexcitability; that have shown aggression over resources or with handling; or that have had a serious illness before 4 months of age)

Can cause dry mouth, vomiting, diarrhea, loss of appetite and inability to urinate Cats may experience hyperexcitability or agitation Diphenhydramine tastes terrible.

Can cause dry mouth, increased thirst, vomiting, diarrhea, loss of appetite and inability to urinate Cats may experience hyperexcitability or agitation Chlorpheniramine maleate tastes bitter.

According to ASPCA Poison Control, tobacco toxicity can result in hyperexcitability then depression, vomiting, incoordination, paralysis and possibly death.

Catego also contains Fipronil which we already know as effective in inducing death in fleas by creating hyperexcitability in their nervous system structures.

Other clinical signs may include fever, weakness or paralysis of hind limbs, impaired vision, ataxia, aimless wandering, walking in circles, hyperexcitability or coma.6 If horse owners notice signs or symptoms of West Nile infection in their horses, they should contact a veterinarian immediately.

Other clinical signs may include fever, weakness or paralysis of hind limbs, impaired vision, ataxia, aimless wandering, walking in circles, hyperexcitability or coma.4 Horse owners should contact their veterinarian immediately if they notice any of these behaviors.

Ensures sustained phenylpropanolamine levels in the blood stream and may help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability

Hyperexcitability in combined entorhinal / hippocampal slices of adult rat after exposure to brain - derived neurotrophic factor