Sentences with phrase «sqle as an oncogene»

But mutated or dysfunctional Rb is associated with several major cancers and Cyclin D has long been described as an oncogene that promotes cancer because it was believed to inactivate the Rb tumor suppressor function through a process called phosphorylation, which involves phosphate molecules being added to proteins, essentially turning them on or off.

Collectively, we established SQLE as an oncogene in NAFLD - HCC and propose that repurposing SQLE inhibitors may be a promising approach for the prevention and treatment of NAFLD - HCC.

«It wasn't known whether miR - 486 functioned as an oncogene or a tumor - suppressor gene in lung cancer,» says co-corresponding author Patrick Nana - Sinkam, MD, associate professor of medicine and a researcher with the OSUCCC — James Molecular Biology and Cancer Genetics Program.

Such genes are referred to as oncogenes.

«This function for BAI1 may have implications for cancer biology, since MDM2 can function as an oncogene by degrading important tumor suppressors like p53.»

In humans, cancer develops when genes that suppress cancer, known as tumor suppressors, are lost and when mutations or genes that promote cancer, known as oncogenes, are gained or activated.

Recent active research in miRNA identified a series of this type of molecules that are involved in tumor progression in various tumors as oncogenes and tumor suppressors (8, 9).

In breast cancer, miR - 21, 155, 27, 96, 182, and 128 were identified as oncogenes, whereas miR - 125, 205, 27, 17, 206, and 145 were found to be tumor suppressor genes, and their corresponding target genes were also defined (10 — 12).

It's particularly because components of the citric acid cycle, specifically isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have recently emerged as oncogenes that are recurrently mutated in gliomas and leukemias.

p53 is therefore well - studied as an oncogene, or a gene that when not functioning normally can contribute to a normal cell becoming cancerous.

Valproic acid reduces histone deacetylation, in effect promoting acetylation, as the oncogene does.

Now researchers are finding additional mutated metabolic enzymes that can behave as oncogenes, says Chi Dang, a medical oncologist and cancer biologist who directs the Abramson Cancer Center, and such discoveries are helping convince skeptics that alterations in metabolism are not mere «epiphenomena» or side effects.

A microRNA — a small piece of RNA involved in regulating gene expression — functions as an oncogene to drive the development of lung...

Consequently, these tumor samples were classified as oncogene - positive.

Using a model where K - ras acts as an oncogene and initiates tumor formation, mice that were bred to not have Notch1 function showed an almost uniform distribution of about two cancerous lesions per mouse after 6 weeks, compared with approximately 14 tumors / mouse for those with Notch1 function still remaining.

Not exact matches

However, the impact of the two methylation - regulating enzymes was still seen at 10 to 15 months, when scientists found decreased expression of hundreds of genes — many of which are key tumor suppressor genes such as BMP3, SFRP2 and GATA4 — in the smoke - exposed cells and a five - or - more-fold increase in the signaling of the KRAS oncogene that is known to be mutated in smoking - related lung cancers.

«Once this novel tumor - homing agent binds to the EphA2 receptor, the oncogene functions as a cancer - specific molecular Trojan horse for paclitaxel, carrying the drug inside the cancel cell, killing the cell, and thwarting metastasis,» said Maurizio Pellecchia, a professor of biomedical sciences at UCR's School of Medicine who led the research.

The oncogenes would be innocuous as long as they remained quiescent.

«Our study identified miR - 182 as a glioblastoma tumor suppressor that reduces the expression of several oncogenes that promote cancer development,» said senior author of the study Alexander Stegh, an assistant professor in the Ken and Ruth Davee department of neurology and of medicine at Northwestern University Feinberg School of Medicine.

This is important as a gene inserted at random could cause cancer if it triggers an oncogene.

Weinberg, who is also a professor of biology at MIT, says he has created cancer cells in culture by adding oncogenes — as, he stresses, have hundreds of others.

Duesberg's constant natter about problems with oncogenes as the cause of cancer seemed to them a distraction, even an obstruction.

In 1984, while Duesberg was researching cellular and viral oncogenes, he heard Margaret Heckler, who was Secretary of Health and Human Services, announce that his then friend Robert Gallo had discovered that HIV was the cause of the mysterious new plague known as AIDS.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene — a gene that promotes the development of cancer — and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival.

The B - raf gene belongs to a class of genes known as «oncogenes,» which send signals to normal cells that cause them become cancerous.

In preclinical experiments using human prostate cancer cell lines, Fu's team showed that increased PLK1 expression activated an oncogene known as c - RAF, which has previously been shown to play a role in regulating cell growth and division.

Wilhelms says the patent as granted includes not only the onco - mouse but other nonhuman mammals with added oncogenes.

That will include validating some of the new predicted tumor suppressors and oncogenes as well as «making some deletions and amplifications and seeing if they have the properties we think they do,» said Elledge.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

As Bialy describes it, everybody cared about cancer, but the only man who understood that it was not caused by oncogenes was scorned by his peers for changing his mind.

But the idea fell out of fashion as researchers began to discover that mutations in specific oncogenes and tumor - suppressor genes could set cancer in motion.

In this study, researchers identified one microRNA (MIR548K) encoded in this region, and found it was characterized as a novel oncogene and functional assays which demonstrated that MIR548K enhances malignant phenotypes of ESCC cells.

In fact, KLF4 blocks senescence and apoptosis by repressing transcription of P53, whereas it can activate P21 - dependent cell - cycle arrest, and therefore, KLF4 can function both as a tumor suppressor and an oncogene (33, 34).

The oncogene was coupled with a fluorescent marker so that cells in which the oncogene was active could be easily identified, and as these cells proliferate, their «daughter» cells could also be tracked.

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context - dependent oncogene

CFSs now appear as preferential targets for oncogene - induced replication stress in precancerous lesions, which suggests that their instability promotes oncogenesis from early stages of the process.

Two proteins that serve as critical inhibitory regulators downstream of the TCR are diacylglycerol kinase ζ (DGKζ), a regulator of Ras and PKC - θ signaling, and Casitas b - lineage proto - oncogene b (Cbl - b), an E3 ubiquitin ligase that predominantly regulates PI (3) K signaling.

With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer.

He served as a member of the graduate faculty in the Department of Molecular Biology at Princeton University and spent 10 years at NIH where he madesignificant contributions to the discovery of a class of proteins known as tyrosine kinase oncogenes as key regulators of the immune system.

Cunningham serves as vice chair of the American Cancer Society Molecular Genetics and Oncogenes Study Section.

«I would have been served so much better if I had stayed with oncogenes as the cause of cancer.»

To sidestep the shortcomings of currently used cancer models, the Salk team harnessed the power of lentiviral vectors to infect nondividing as well as dividing cells and ferry activated oncogenes into a small number of cells in adult, fully immunocompetent mice.

Because Akt is an important oncogene that is frequently deregulated and shows high activity in many hematological and nonhematological malignancies, using VPA to prevent or treat GVHD may reduce the severity of GVHD, as well as have a salutary effect on inhibiting the relapse of hematological malignancies.

Development of inhibitors of metabolic pathways to block oncogenes or signalling molecules in malignant processes and specific inflammatory processes, such as pulmonary artery hypertension or idiopathic pulmonary fibrosis.

Similarly, microarray analyses comparing global gene expression in cells that overexpress wild - type STAT3 or phosphorylation - deficient mutant indicate that a subset of genes are regulated by unphosphorylated STAT3, including well - known oncogenes such as MRAS and MET (Yang et al., 2005).

In response to cellular stress such as DNA damage, oncogene activation, transcriptional inhibition, and hypoxia, tumor suppressor p53 is activated and expressed, and acts as a transcription factor to induce its target genes [1], thereby playing a central role in the regulation of DNA repair, cell cycle, apoptosis, senescence, and angiogenesis [2 - 4].

This often identifies thousands of potential targets and sometimes misses important ones like the oncogene RAS as a target of let - 7.

Thus, she proposed that many determinants of metastasis are likely to be oncogenes as well.

The most striking chromatin modification is the formation of heterochromatic foci, termed as senescence associated heterochromatic foci (SAHF), often induced by the activation of oncogenes such as Ras.