In 1970 Duesberg, along with a colleague, Peter Vogt, isolated the RSV gene responsible for causing those tumors —
the SRC gene.
It appears the vertebrate
src gene has survived long periods of evolution without major change, implying that it is important to the well - being of the species in which it persists.
We reasoned that if the hypothesis was correct, we might be able to find
the src gene (the oncogene of the Rous sarcoma virus) in the DNA of normal cells.
Not exact matches
UT Southwestern biochemists studying mouse models found that the two proteins − steroid receptor coactivators 1 and 2 (
SRC - 1 and
SRC - 2)-- control
genes for pulmonary surfactant components that promote the initiation of labor.
It is a cellular
gene, which is now called c -
src.
Apart from their introns, the versions of c -
src found in fishes, birds and mammals are all closely related to the viral
gene v -
src and to one another.
«Our study provides compelling evidence that the fetus regulates the timing of its birth, and that this control occurs after these two
gene regulatory proteins −
SRC - 1 and
SRC - 2 − increase the production of surfactant components, surfactant protein A and platelet activating factor,» said senior author Dr. Carole Mendelson, Professor of Biochemistry, and Obstetrics and Gynecology at UT Southwestern.
UT Southwestern researchers found that the proteins
SRC - 1 and
SRC - 2 activate
genes inside the fetus» lungs near full term, resulting in an increased production of surfactant components, surfactant protein A (SP - A), and platelet - activating factor (PAF).
AFRICAN GREEN MONKEY CELL: An African green monkey kidney cell expressing the
gene c -
src, imaged using Bessel beam plane illumination.
The study showed that a number of known cancer
gene mutations, such as APC, PI3KCA,
SRC and p53, exercise their effects through microRNA 135b.
«Because the Met -
SRC complex regulates a
gene that controls reproductive development in crustaceans, we know that such activity means there is a significant likelihood of environmental toxicity — enough to make it a priority for in - depth toxicity testing,» LeBlanc says.
Other
genes can influence how well this
gene does its job (
src).