The reverse was true, too:
Saccharin blocked TAS2R1 — one of the bitter receptors that cyclamate activates.
Saccharin blocks subtype 1.
Not exact matches
So it's probably the actions of cyclamate at
saccharin's bitter receptors that help
block the bitterness, Behrens and his colleagues report September 14 in Cell Chemical Biology.
In this case, though, the amount of
saccharin required to
block the receptors that cyclamate activates would have bitter effects on its own.
It's not too surprising that a sweetener might
block some receptor subtypes and stimulate others, he notes, but that
saccharin and cyclamate have such clear compatibilities is a lucky chance.
It turns out that
saccharin doesn't just activate sweet taste receptors, it also
blocks bitter ones — the same bitter taste receptors that cyclamate activates.
In fact, you would need so much
saccharin to completely
block cyclamate's bitterness that the
saccharin's own bitterness would become overwhelming.
It also
blocks the bitter receptors that
saccharin stimulates.
But
saccharin doesn't
block the receptor very well.