Sentences with phrase «schwann cell precursors»

In March, the U.S. Food and Drug Administration (FDA) approved BLINCYTO for the treatment of adults and children with B - cell precursor acute lymphoblastic leukemia in first or second complete remission with minimal residual disease (MRD) greater than or equal to 0.1 percent.

The drug, which was first approved last August for patients under 25 with B - cell precursor acute lymphoblastic leukemia, is now OK» ed to treat large B - cell lymphoma.

Usually imprinting marks are erased in the germ cell precursor cells and then rewritten in the eggs or sperm.

Why leukemic cells and normal blood cell precursors respond so differently to this treatment requires further investigation.

One company, Melbourne, Australia — based Mesoblast, is already in late - stage clinical trials, treating hundreds of chronic heart failure patients with stem cell precursors drawn from healthy donors» hip bones.

Nadeau stumbled upon one study, in mice, describing how environmental factors can tag Foxp3 with chemical markers that tell T - cell precursors to switch the gene on or off.

In theory it is possible to transform either somatic cells (most cells of the body) or cells of the germline (such as sperm cells, ova, and their stem cell precursors).

The other kind is peritubular — that is, located on the surface of the seminiferous tubules that house sperm cell precursors.

«Insights into the development of sperm and egg cell precursors in the embryo.»

The antibody fragment was selected because it uniquely binds to the cell membranes of red blood cell precursors while avoiding other types of blood cells that control clotting and vessel growth.

Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic white blood cell precursors become leukemia stem cells.

Ultimately, this activity increases cellular regeneration, or self - renewal, turning white blood cell precursors into leukemia stem cells.

Much like chemotherapy's well - known ability to decrease red and white blood cell precursors transiently, methotrexate or cyclophosphamide depleted fat cell precursors, leading to much decreased fat storage.

The dorsal region spontaneously developed three layers along the dorsal - ventral axis: the ventricular zone, a Purkinje - cell precursor zone, and a rhombic lip zone.

They observed that the fly was born alive but without wings; so the removal of this molecule caused the death of all cell precursors of this tissue (if histone 1 is removed from the entire fly, the embryo dies).

In 2014, the FDA approved Amgen's BLINCYTO ® (blinatumumab), the first BiTE ® therapy to receive FDA approval, for the treatment of Philadelphia chromosome - negative relapsed or refractory B - cell precursor acute lymphoblastic leukemia, a rare and rapidly progressing cancer of the blood and bone marrow.

By carefully guiding the cells» choices at each fork in the road, Loh and Chen were able to generate bone cell precursors that formed human bone when transplanted into laboratory mice and beating heart muscle cells, as well as 10 other mesodermal - derived cell lineages.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

The genetic basis of early T - cell precursor acute lymphoblastic leukaemia Nature, 481 (7380), 157 - 163 DOI: 10.1038 / nature10725

Other CAR T - cell therapies approved in 2017 include tisagenlecleucel for the treatment of children and young adults up to 25 years of age with relapsed or refractory B - cell precursor acute lymphoblastic leukemia and axicabtagene ciloleucil (aci - cel; Yescarta) for adults with relapsed or refractory DLBCL.

Single cell analysis identifies new immune cell precursor; reveals surprising heterogeneity in a poorly understood subgroup of antiviral T lymphocytes

Her newest project, funded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, will look at the crucial time when malaria is transmitted — when reproductive cell precursors known as gametocytes develop.

He is a pioneer of the field called «adult stem cell biology» and has isolated of various blood cell precursors in mice.

In a study published earlier this year, the same Belmonte and Gage lab team demonstrated that a few ES cells in a culture dish tended to lose stemness and evolve into muscle cell precursors, most likely goaded by a muscle differentiation factor known as BMP.

They usually are the result of acquired (not inherited) genetic mutations that occur only in the red blood cell precursors that lead to ringed sideroblasts.

Not exact matches

The aged egg, which may have had damaged mitochondria that wouldn't work as well, then has fresh mitochondria from the egg precursor cells to generate energy.

For biologists, 14 days marks the start of cell differentiation: before this, the embryo has no precursors of nerves or blood, so it can not possibly know or experience anything.

The raw materials that feed this voracious sperm factory are sperm precursor cells, called spermatogonia.

Cholesterol is required for building and maintaining cell membranes, and is the precursor to several essential hormones.

Extracts from nine samples spurred the cells to divide, creating a larger pool of precursor fat cells.

The suggestion is that a small number of such cells within tumours may be the precursors to the other cancer cells in those tumours.

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

The reset cells, known as induced pluripotent stem cells (iPS cells), gave rise to healthy precursors of bone marrow stem cells (Nature, DOI: 10.1038 / nature08129).

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Although the face and heart don't end up so close together, they arise from the same type of precursor cells called neural crest cells.

This protein is expressed at relatively high levels in proliferating precursors and non-neuronal cells but down - regulated in developing neurons by a brain - enriched regulatory RNA called miR - 9.

They first devised a nanoscale plastic scaffold and then seeded it with common muscle precursor cells called myoblasts, along with endothelial cells of the sort found on the inside of blood vessels.

Higher amounts of insulin are more likely to cause cells to lose their ability to regulate growth, a precursor to cancer.

The process involves the reversion of delta cells (which produce somatostatin, another pancreatic hormone) to a precursor - like cell state, with proliferation and later reconstitution of the populations of beta and delta cells.

During normal brain development in the first weeks of life, precursor cells in the SVZ in the piglets give birth to neurons that migrate primarily to the prefrontal cortex, the team reports today in Science Translational Medicine.

«Esophageal cancer «cell of origin» identified: In mice, basal progenitor cells give rise to Barrett's esophagus, a precursor to cancer.»

But researchers reporting online April 14 in Nature Cell Biology claim they have found precursor stem cells in newborn and adult mice that could be prodded into producing new eggs.

A technician then examines the sample under a microscope for the oddly - shaped cells that are a precursor to cancer.

Ductal carcinoma in situ (DCIS) is a precursor of breast cancer where the cancerous cells are contained within the milk - making ducts.

The brains of the human babies with CHD that died in the first month of life also showed a depletion of neural precursor cells in the SVZ.

In newborn mammals, the SVZ is the biggest depot for the precursor cells that migrate to populate various brain regions, and differentiate into multiple cell types.

By tweaking different fly genes and counting how many neuron types were produced as the flies matured, the team identified a network of five genes that work together like coordinated control switches to guide the precursor cells» transformation to mature neurons.

All precursor cells have the same DNA, and how they produce one neuron type versus another was unknown.

Smell neurons begin as identical precursor cells, immature cells that have not yet «decided» which type of nerve cell they will become.

Columbia University Medical Center (CUMC) researchers have identified cells in the upper digestive tract that can give rise to Barrett's esophagus, a precursor to esophageal cancer.