Sentences with phrase «see synthesis report»

Not exact matches

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

What we have NOT seen is an improvement in the science itself, in it's openness, in sharing data and code, in admitting uncertainty, in including dissenting views in synthesis reports.

There are plenty, but for a conservative example see IPCC Synthesis Report 2007 Table 5.1 which says to stay within 2 - 2.4 degrees global average temperature increase above pre-industrial (Copenhagen upper «low risk» target) and 425 - 490ppm CO2 - equivalent concentration at stabilisation, the required change in global CO2 emissions in 2050 (percent of 2000 emissions) is decline between 85 to 50 percent.

I may have misunderstood something, but looking at the 2 °C curve I couldn't see how the cumulative emissions fit with the 50 % chance of 2 °C carbon budget from the Synthesis report.

It's a style issue in a way, but I've never seen synthesis or other group reports referred to as simply Anon before.