«This
study gives a glimpse into the mechanism by which different mutations within the same gene can cause distinct defects in the brain, and may help to explain how they may contribute to different disorders,» says Guoping Feng, the James W. and Patricia Poitras Professor of Neuroscience at MIT, a member of MIT's McGovern Institute for Brain Research, a member of the
Stanley Center for Psychiatric Research at the Broad Institute, and the
senior author of the
study.
The Director of the UC San Francisco Institute,
Stanley B. Prusiner, MD, UCSF professor of neurology, biochemistry and biophysics, won the Nobel Prize in Physiology or Medicine in 1997 for discovering that the neurodegenerative diseases known as spongiform encephalopathies were caused by prions.2 Prusiner and Stephen A. DeArmond, MD, PhD, UCSF professor of pathology and chief of the Division of Neuropathology, were the
senior authors of the
study.