Sequencing efforts in the past few years have pushed the number closer to 1,000 (ref.
«This study demonstrates the benefit of broad - based
sequencing efforts in personalized oncology.
Not exact matches
Venter, who is one of the first people to
sequence the human genome, co-founded the company
in effort to discover early genetic markers for a variety of disorders.
But rather than buying up a genetic research outfit, it decided to build its own
in the form of the Regeneron Genetics Center (RGC), an ambitious four - year old
effort to
sequence as many exomes (the protein - encoding part of the genome) as possible, pair them with medical records, and accelerate drug development.
It can be argued that (1) the longer version was written by Luke and the confusion is due to the
sequence cup - bread - cup, not found
in early liturgies and therefore disliked by early copyists, or (2) what Luke wrote was only the shorter version (cup - bread, as
in the Didache); the confusion is due to the
efforts of copyists to supply additional materials.
Most importantly, he blocked an Arsenal
effort in a chaotic
sequence, which even the superhuman De Gea was unlikely to stop.
«We have discovered that the two more destructive pathogens share a pattern of parallel changes
in their core metabolic pathways that enables them to exploit more efficiently the nutrient resources available
in banana,» said Stergiopoulos, who along with bioinformatician Ti - Cheng Chang, led the
effort to
sequence and analyze the fungal genomes of eumusae leaf spot and yellow sigatoka, comparing their findings with the previously
sequenced black sigatoka genome
sequence.
«Intensive DNA
sequencing efforts to find the genetic «drivers» of metastasis, which is what kills patients
in up to 80 percent of cases, have thus far been disappointing, to say the least,» he said.
To aid
in relief
efforts and facilitate rapid global research, we have immediately released all
sequence data as it is generated.
A consortium of peanut growers, peanut shellers, brokers and food manufacturing groups provided $ 6 million
in funding for the genome
sequencing effort through The Peanut Foundation.
She has
sequenced hundreds of tumor samples from across the island
in an
effort to understand how it evolves and how that affects the devils» survival rates.
The 15 AACR scientists, who were already
in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor genome -
sequencing efforts and getting the government to cover the costs of genomic tumor profiling.
Along the way he led BGI, which moved to Shenzhen
in 2007, into some of its most ambitious projects, including an ongoing
effort to
sequence 10,500 bird genomes.
The genes of 50 top bulls have been
sequenced in an
effort to understand how genes from temperate cattle have influenced important production traits
in the modern Brahman breed.
«
In addition to funding rice sequencing, the [Thai] government is about to launch an effort that will move on to functional genomics,» says Apichart Vanavichit, a molecular biologist at Thailand's National Center for Genetic Engineering and Biotechnology in Nakorn Pathom, which is helping to sequence chromosome
In addition to funding rice
sequencing, the [Thai] government is about to launch an
effort that will move on to functional genomics,» says Apichart Vanavichit, a molecular biologist at Thailand's National Center for Genetic Engineering and Biotechnology
in Nakorn Pathom, which is helping to sequence chromosome
in Nakorn Pathom, which is helping to
sequence chromosome 9.
In fact two projects, a public
effort and a private venture, had competed to capture the
sequence.
Lo was encouraged by the variants because retroviruses are extremely mutable pathogens that change their gene
sequences again and again
in response to immune system
efforts to kill them.
The largest population genome
sequencing effort to date is published
in Nature.
Rapid advances
in genome
sequencing have provided promising new techniques to help researchers conserve endangered species, but
efforts to resurrect extinct animals raise complex legal, ethical and environmental questions, experts said at a 4 November event at AAAS.
As scientists began to
sequence human genes
in the 1990s, sorting out the cellular locations of each gene's proteins became a priority, says Mathias Uhlén, a microbiologist at the Royal Institute of Technology
in Stockholm, Sweden, and director of the Protein Atlas
effort.
To demonstrate the utility of the gorilla Y chromosome
sequence they generated, the researchers designed genetic markers that can be used to differentiate the genetic relatedness among male gorillas and thus to aid
in conservation genetics
efforts targeted at preserving this endangered species.
The barley genome
sequence also enabled the identification of regions of the genome that have been vulnerable to genetic bottlenecking during domestication, knowledge that helps to guide breeders to optimize genetic diversity
in their crop improvement
efforts.
This was a daunting task, as the barley genome is almost twice the size of the human genome and 80 percent of it is composed of highly repetitive
sequences, which can not be assigned accurately to specific positions
in the genome without considerable extra
effort.
Their DNA was the basis of the first
effort to compile a complete Neandertal genetic
sequence, which was published
in 2010.
Last year, SciLifeLab researchers also joined an
effort to
sequence the genomes of microbes living
in the Baltic Sea.
Efforts to put individual genome
sequences and accompanying personal health information online
in a freely accessible database just got a boost
in the United Kingdom.
This
effort involves first generating lots of tiny, overlapping bits of DNA that must be assembled
in the right order after their nucleotide
sequences are determined.
Large - scale genome
sequencing efforts, like the Human Microbiome Project, have focused on the community of microorganisms that live
in the human gut.
When it is complete
in 2008, EarthScope's web of instruments will provide public data for geoscience, not unlike the way the human genome
sequencing effort has for biology.
At Weill Cornell, Imielinski is participating
in the precision oncology
effort, which will
sequence tumor DNA to match patients to particular therapies.
«Their performance has been remarkable,» says Richard Gibbs, who heads the public
sequencing effort at Baylor College of Medicine
in Houston.
In today's Nature Genetics, researchers report that they have produced a so - called optical map of the parasite's 14 chromosomes, an achievement that should aid the ongoing
effort to
sequence the Plasmodium genome.
In this research
effort, scientists conducted DNA
sequencing on more than 500 adults and children with DCM and more than 1,100 healthy controls from several ethnically distinct cohorts to learn about the genetic profile of the disease.
Participants are enrolled
in MSSNG, an
effort funded by Google and the nonprofit group Autism Speaks to analyze
sequences from 10,000 people.
Her lab selected and grew the algae for
sequencing in a collaborative
effort with CIFAR Fellow Adrián Reyes - Prieto, who she first met at the Institute's program meetings.
In the latest
sequencing effort, Willerslev and researchers from Denmark, China, and the United States analyzed the genomes of 80 polar bears from Greenland and 10 brown bears from North America and Europe.
Warinner began her graduate studies at Harvard
in 2004, just after the
sequencing of the human genome was completed and by the time she left
in 2010,
efforts to survey the human microbiome were
in full swing.
As part of a long - standing
effort to study the rampant drug - resistant TB
in Samara, a region of Russia about 1,000 kilometers southeast of Moscow, researchers collected TB isolates from 2,348 patients and
sequenced the entire genomes of 1,000 of them.
One way to conceptualize these systems is to think of the processes involved
in driving a car: the novice needs to rely on controlled processing, requiring focused concentration on a
sequence of operations that require mental
effort and are easily disrupted by any distractions.
Another researcher, Richard A. Finkelstein, said that participation
in American Society of Microbiology (ASM) meetings supported his
efforts to isolate and
sequence toxins that cause cholera, a deadly intestinal disease.
Another attendee was Craig Venter, who led a private
effort to
sequence the human genome
in the late 1990s that competed with a public
effort led by Collins.
The
sequencing effort was a collaboration among IRRI; BGI
in Shenzhen, China; and the Chinese Academy of Agricultural Sciences
in Beijing.
One well - accepted
effort compares the nucleic acid
sequences that code for ribosomal RNA and a few proteins
in many different organisms.
If such
efforts succeed, says Robert Waterston, a geneticist who heads the genome
sequencing center at Washington University
in St. Louis, Missouri, the technique «could be the start of something impressive.»
PARIS — Scientists have agreed to collaborate on an eagerly awaited
effort to
sequence the genome of the mosquito Anopheles gambiae, the main vector for the malaria parasite
in sub-Saharan Africa.
In an
effort to better understand and help combat the ants, a group of researchers led by Neil Tsutsui at the University of California, Berkeley,
sequenced the genome of L. humile.
Richard Gibbs and colleagues at the genome center at Baylor College of Medicine
in Houston, Texas, will lead the
effort, and a group at Celera Genomics
in Rockville, Maryland, will add brute - force
sequencing power.
«Understanding how Cas9 is able to locate specific 20 - base - pair target
sequences within genomes that are millions to billions of base pairs long may enable improvements to gene targeting and genome editing
efforts in bacteria and other types of cells,» says Doudna who holds joint appointments with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Department of Molecular and Cell Biology and Department of Chemistry, and is also an investigator with the Howard Hughes Medical Institute (HHMI).
It has launched projects such as a major
effort to develop knock - out mice (ScienceNOW, 7 September 2006) and The Cancer Genome Atlas (Science, 16 December 2005, p. 1751), which, with the cancer institute, is
sequencing mutations
in human cancers.
Both public and private
efforts published a rough draft
in 2001 and the full
sequence was completed
in 2003.