Sentences with phrase «sequencing nuclear genomes»

Sequencing nuclear genomes requires sequencing the DNA library many times over, increasing the «depth» of sequence reads at each base.

And sequencing his nuclear genome — the genetic information inherited from both parents — and that of other ancient specimens could give a more complex picture of the way groups mixed with one another.

«The only way to get a real story, the closest we can get, is to sequence nuclear genomes from orchids,» says Victor Albert, a plant geneticist at the State University of New York at Buffalo.

Not exact matches

Overall, a study of the genome sequences of 57 colorectal cancers showed, on average, 4.42-fold more somatic nuclear mitochondrial DNA as compared to matched healthy blood controls.

Due to the limited number of specimens and difficulties in obtaining endogenous DNA from such old material, the number of Neandertals for which nuclear genomes have been sequenced is still limited.

Researchers were sequencing mitochondrial DNA from aurochs remains (and would successfully sequence the first nuclear genome in 2015).

«For chloroplast genome recovery from total DNA sequence data, the deliberate identification of reads that represent chloroplast DNA inserts into the nuclear genome allowed us to attain a higher - quality chloroplast genome assembly in a time - and cost - effective way,» Garaycochea explains.

Thousands of plant species have had their genomes sequenced, but without organelle genomes, nuclear genomes are only one piece of the DNA puzzle.

This timeline highlights key discoveries about our closest relatives, from early fossil finds to the publication of the draft nuclear genome sequence.

Subsequent sequencing of the nuclear genome followed, revealing that the pinkie came from a previously unknown hominid group, similar to Neanderthals, that migrated east toward Asia while Neanderthals migrated west.

Using what's called true single molecule sequencing, Orlando lit up the A's, C's, T's and G's, one by one, to assemble the horse's genome — six times older than any nuclear DNA specimen ever sequenced.

Then, in 2010, Pääbo and colleagues published a draft sequence of the Neanderthal's nuclear genome — 4 billion nucleotides — based on three individuals.

They sequenced the entire nuclear genome of this species, and identified all of the genes within that genome that code for biological functions.

Yet the discovery shows that with ever - cheaper genetic sequencing and faster computers, it is possible to recover a full nuclear DNA sequence from an ancient human, even when the genome is broken into tiny fragments.

Dr. Donovan Bailey, senior author of the study and professor at New Mexico State University, said this approach has several advantages over previously established methods for enriching either nuclear or organellar DNA for genome sequencing.

Pääbo's group first gave the field a jolt in May 2010 by reporting a low - coverage sequence (1.3 copies on average) of the composite nuclear genome from three Neandertals.

The branch uniting the fungi and animals is well - supported based on a number of molecular phylogenetic datasets, including the nuclear small subunit ribosomal RNA gene (Wainwright et al., 1993; Bruns et al. 1993), unique and shared sequence insertions in proteins such as elongation factor 1α (Baldauf and Palmer, 1993), entire mitochondrial genomes (Lang et al., 2002), and concatenated protein - coding genes (Steenkamp et al., 2006).

Characteristics of the tomato nuclear genome as determined by sequencing undermethylated EcoRI digested fragments Wang, Y., R. S. V. D. Hoeven, R. Nielsen, L. A. Mueller et al. 2005.

In 2014 alone, scientists successfully sequenced the mitochondrial genome of a hominin that lived more than 400,000 years ago, 1 exomes from the bones of two Neanderthal individuals more than 40,000 years old, 2 and a nearly complete nuclear genome from a 45,000 - year - old modern human fossil, 3 to name but a few.

To avoid including reads sequenced from regions of the nuclear genome sharing high similarity with mitochondrial DNA (NUMTs), reads that did not map uniquely to the mitochondrial genome were discarded using SAMtools [32, 33].

Here we utilize whole - genome sequencing of Roifman Syndrome patients to reveal compound heterozygous rare variants that disrupt highly conserved positions of the RNU4ATAC small nuclear RNA gene, a minor spliceosome component that is essential for minor intron splicing.

We have gone from sequencing small fragments of DNA to full mitochondrial genomes (17,000 base pairs of genetic code), and then in the last three years the field exploded into the realm of complete nuclear genomes.

(b) Archaeogenomic relatedness results for mtDNA (nucleotide sequence similarity to burial 14) and the nuclear genome.

It is so good, in fact, that there is a possibility that its entire mtDNA genome may be able to be sequenced, and there is even a possibility that some of its nuclear DNA may be retrievable.

With recent announcements of plans for sequencing the genome from present - day polar bear (34) offering a necessary reference, future sequencing of all or a substantial fraction of the nuclear genome of this exceptionally well preserved Pleistocene polar bear specimen may be feasible.