(A)
Serum cytokine levels in immunized and control mice (n = 8 — 12).
Not exact matches
They both had considerable systemic inflammation, which can be measured by
levels of multiple pro-inflammatory
cytokines in the blood
serum.
Serum levels of the proinflammatory
cytokines IL - 6 and TNF - α were unchanged in immunized mice, whereas the anti-inflammatory
cytokine IL - 10 was significantly depressed (Fig. 2A).
(G)
Serum levels of
cytokines from VPA recipients and control mice on days 7, 14, and 28.
The infiltration of Th1 and Th17 cells into GVHD target organs (liver and lung), as well as the
serum level of related
cytokines, also were increased in allogeneic BMT recipients.
We also detected substantially lower
serum levels of Th1 - and Th17 - related
cytokines (e.g., TNF - α, IFN - γ, IL - 17A, IL - 21, and IL - 23) in VPA recipients (Fig. 2G).
Moreover, the infiltration of Th1 and Th17 cells into GVHD target organs, as well as the
serum level of proinflammatory
cytokines, were significantly decreased.
Mouse
serum was collected on days 7, 14, and 28 after BMT, and the
levels of
cytokines were measured using ProcartaPlex Multiplex Immunoassays (eBioscience).
White adipose tissue messenger RNA
levels and
serum concentrations of inflammatory
cytokines (tumor necrosis factor - α, interleukin - 6, and monocyte chemoattractant protein - 1) were reduced by C3G, as did macrophage infiltration in adipose tissue.
In addition, an increase was observed in
serum levels of anti-inflammatory
cytokine IL - 10 and also in
serum levels of IL - 6.