Sentences with phrase «setdb1 during differentiation»

It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs.

The new technique could also be useful in understanding how stem cells change oxidation properties during differentiation into other cell types.

«We also think this method could be applied towards the development of culture conditions during differentiation of human stem cells.

In order to learn more about this process, Alexander Skupin and his team treated blood stem cells from mice with growth hormones and then watched closely how these progenitor cells behaved during their differentiation into white or red blood cells.

The team identified 29,857 regions on the genome that respond to regulatory proteins and then tracked levels of activity at six instances during the differentiation.

Using ES cells developed at Kyoto University's Institute for Frontier Medical Sciences, the research group collected RNA and histones of each cell immediately after VEGF stimulation (0 h), before differentiation (6 h), during differentiation (12 — 24 h), and after differentiation (48 h).

Ammonia, accreted either as organic matter or as ice, may have reacted with phyllosilicates on Ceres during differentiation.

Expression of MyoD, a skeletal muscle - specific transcriptional regulator, activated the expression of the Cdk inhibitor p21 during differentiation of murine myocytes and in nonmyogenic cells.

Interestingly, studies have indicated that a short G1 phase is a hallmark of pluripotent stem cells (PSCs)[2, 3], only lengthening during differentiation [4].

Recent studies have started to map the gene - wide chromatin interactions in the interphase nucleus, revealing some principles of chromosome organization into territories, and dramatic changes of chromatin organization and interactions during differentiation and lineage specification.

Mechanistically, we observed that Wnt / ß - catenin signaling orchestrates the cytoplasmic relocalization of the histone 3 lysine 9 methyltransferase Setdb1 during differentiation.

Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell - derived cardiomyocytes during differentiation.

Endogenous optical signals reveal changes of elastin and collagen organization during differentiation of mouse embryonic stem cells.

VASA expression increased during the differentiation of monkey ES cells, indicating that these cells have the ability to differentiate into a germ cell lineage in vitro.

This short review, part of the Thematic Series on Raman Spectroscopies, describes the application of Raman micro-spectroscopy to measure the molecular properties of stem cells during differentiation in - vitro.

For example, the expression of BMP - Smad signaling pathway components is low during differentiation of mDA neurons from their VM neural precursors in vivo (E10 — E12), yet after this period, these subsequently increase in expression and play a functional role in mDA neuronal outgrowth (E1 — E18)[37].

The H1 - Oct4 - EGFP cell line expressed EGFP, which turned off during differentiation (Fig. 6A).

267/4: 30 Extremely high resolution 3D maps of human and mouse genomes across lineages and during differentiation reveal principles of chromatin looping.

Genes involved in DNA damage control and inhibition of DNA synthesis [49], in particular Atm, Chk1 and Chk2, are also highly expressed in ES cells, but decline during differentiation.

Finally, we analyzed ESTs separately to distinguish the ones that are expressed in ES cells or during the differentiation process.

Compared to PHWSC adipocytes, SGBS adipocytes showed not only greater induction of adipogenic gene expression during differentiation but also increased levels of UCP1 mRNA and protein expression.

Conversely, few pro-apoptotic genes are expressed in ES cells (day 0; most boxes appear in green), but many are gradually induced during the differentiation process showing the exact opposite pattern from the genes involved in cell proliferation (Figure 7).

The bottom row consists of three tools that offer: detailed organization of specific gene expression patterns (Expression Waves) during the differentiation process (bottom left); animation of KEGG pathways organized by successive days of differentiation (Pathway Animations, bottom middle); and, a search engine to obtain the expression of any transcript or groups of transcripts in the Affymetrix 430 v. 2 arrays during the ES cell differentiation process (bottom right).

It is possible that the Oct4 expression patterns that we observe is due to failure of one or more of these processes in the complex, abnormal milieu of this embryonal carcinoma cell line during differentiation.

Not exact matches

To help further strengthen brand equity and differentiation within the category, during the second quarter, LongHorn will introduce a new menu design, distinctive new steak offerings and a new advertising campaign that more effectively communicates their passion for delivering a great steakhouse experience with a little more attitude than the current campaign, which we believe will help further differentiate the brand.

Her positive relationship with food strayed off course during adolescence because of the mixed messages regarding nutrition, the differentiation between «good» and «bad» foods, and diet culture.

This differentiation may become obvious with the first appearance of colostrum during the secretory development phase in the second half of gestation.

SHEILA GROVE: I love the way the Gina described it because she was kind of able to vocalize some of the differentiation that we initial feel during the breastfeeding.

Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS - 2.

Objective 4: Describe 3 anatomic changes associated with breast tissue differentiation during pregnancy.

Stage I lactogenesis, or secretory initiation, occurs during pregnancy and is defined by the differentiation of mammary alveolar epithelial cells into specialized secretory cells, termed lactocytes (1).

The differentiation campaign would begin in April, during the European elections campaign, and continue until September and the Lib Dems» final autumn conference before next year's general election.

All the interdisciplinary skills and knowledge he had gathered during his scientific training — which had covered biochemistry, biotechnology, biomaterials, and stem cell biology — put him «in a very advantageous position to address this question» of how to develop nanoparticles that could modulate stem cell differentiation on demand, he says.

Up until now, however, it has been unclear what comes first during cardiomyocyte differentiation: the reorganization of the DNA's folding in the cellular nucleus or the DNA's methylation — and whether these mechanisms are dependent on one another.

However, it remains unclear how these different stem cells populations balance proliferation, differentiation and migration during the healing process.

The study focuses on «stemness,» defined as the potential for self - renewal and differentiation from the cell of origin, and on «stemness indices» developed during postdoctoral research conducted by Tathiane Malta as part of a project supported by FAPESP and with Houtan Noushmehr, a professor in FMRP - USP's Genetics Department, as principal investigator.

Instead, they are actually supplied by first progenitor cells that develop during the following differentiation step.

Immunoglobulin K genes are constructed during lymphocyte differentiation by the joining of two DNA elements, VK and JK, to form both a VKJK coding unit and a reciprocal recombination product.

The studies also revealed when during taste cell differentiation these genes influence whether a given taste cell ultimately will respond to either salty, sweet, sour, bitter or umami.

More importantly, the fibronectin part of the complex is expressed during a cell's transition to cancer and plays a role in cell growth, migration and differentiation.

Senior researcher Mori continues, «We see UPR working «backstage», so to speak, to support the main actors during cell differentiation and thereby orchestrating various biological processes»

The scientists conclude that the study reveals an essential function for CTCF in the orchestration of transcriptional changes during the terminal differentiation of B lymphocytes and advances understanding of the mechanisms that regulate the immune response.

In most placental mammals, the Y chromosome induces male differentiation during development, whereas embryos without it become female.

The research is titled «Transcription, Signaling and Metabolic Transitions During Human Spermatogonial Stem Cell Differentiation.»

The lack of genetic differentiation (aside from the Caprivi Strip) is consistent with historical evidence of elephant movements during the Namibian War of Independence, which increased hunting pressures.

The completion of differentiation correlated with less aberrant methylation during the reprogramming process.

Their findings outlined four distinct cellular phases of sperm stem cells maturation, revealing how the stem cells progress from a «quiescent» state, to a «proliferation» state during which stem cells divide, to a final «differentiation» state when stem cells mature to become sperm.

In the case of planarians, the gene egr - 4 seems to perform an early control of cell proliferation as a response to amputation, and be involved later in the early differentiation of brain during regeneration.

«Probably, any molecule related to the nervous systems induce cell proliferation or differentiation during regeneration,» remarks Francesc Cebrià.

One of the key metabolic alterations that takes place during EMT is that of the epidermal growth factor receptor (EGFR) which is a pathway that regulates growth, survival, proliferation, and differentiation in mammalian cells.