Several methodological approaches have been developed for NIPD of cystic fibrosis, which is the most common life shortening, childhood onset autosomal recessive disorder in populations of European descent.
Still in its R&D phase, Oraclum will engage in experimental testing of
several methodological approaches within the BAFS to pick out the best one.
Not exact matches
There are
several methodological problems with the typical implementation of both of these
approaches.
Here too, there are
several questionable
methodological choices, including a simplistic principal component
approach that is almost certainly overfitting (for example, 10 principal components to represent 90 plus proxies seems excessive on its face).
Comment:
Several commenters took issue with the «top - down»
approach that we used to estimate costs for small businesses, believing that this methodology provided only a single point estimate, gave no indication of the variation around the estimate, and was subject to numerous
methodological errors since the entities to which the numerator pertained may not have been Start Printed Page 82757the same as the denominator.