Mini Transplant May Reverse
Severe Sickle Cell Disease Results of a preliminary study by scientists at the National Institutes of Health and Johns Hopkins show that «mini» stem cell transplantation may safely reverse
severe sickle cell disease in adults.
bluebird bio (BLUE)- The company's BCMA CAR - T drug candidate bb2121 remains attractive despite overblown fears on durability (peak sales of $ 2 billion or more), LentiGlobin has a good shot at success in TDT (Transfusion - Dependent ß - Thalassemia) and SCD (
Severe Sickle Cell Disease), and they have a strong cash position.
Not exact matches
Yes the home group will contain some higher risk moms (some VBAC, some breech, some GDM) but it won't contain the full spectrum of high risk that the hospital gets: Women with clotting disorders on heparin, maternal heart
disease, moms addicted to crack, moms with HIV, 12 and 13 year olds, women who walk in off the streets in labor with no prenatal care, women with
sickle cell and cystic fibrosis and type 1 diabetes, babies with
severe anomalies.
These
diseases include leukemia or lymphoma, aplastic anemia,
severe sickle cell anemia, and
severe combined immune deficiency.
Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use
Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart
disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear
Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking Drug use
Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart
disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear
Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
«If we could use gene editing to remove the sequences in an embryo that cause
sickle cell disease or cystic fibrosis, I would say not only that we may do so, but in the case of such
severe diseases, we have a moral obligation to do so.»
Either approach could produce enough HSCs to transplant and — pending further safety testing — potentially treat leukemia,
sickle cell disease and other
severe blood disorders.
Patients with
sickle cell disease are commonly prescribed a daily, long - acting painkiller taken at a constant dose, and a short - acting painkiller to be taken as needed for episodes of more
severe pain.
Clients with a more
severe type of
sickle cell disease may need to consider purchasing burial life insurance from one of the top 10 best final expense companies.