Sentences with phrase «signalling analyses indicate»

Signalling analyses indicate a connection between the androgen receptor and the mTORC1 pathway, possibly via AMPK.

Not exact matches

Statistical analyses of the number of Acks signals detected in in situ hybridization experiments using sections of brains of heat - exposed (n = 6) and non-treated control workers (n = 5) indicated that the numbers of Acks signals significantly increased in the Class I and Class II KCs and in the brain area between the DLs and the OLs in the heat - exposed workers compared with those of control workers, whereas there were no significant differences of the number of Acks signals in the OLs (Figure 5M).

Statistical analyses indicated that the Acks signal density decreased to approximately 45 % by antennae deprivation in heat - exposed workers (Figure 5M), suggesting that there is some unknown projection (s) from the antennal thermoreceptive neurons to the Class II KCs.

MALDI - MS analysis revealed an absence of Aβ signal in non-transgenic animals (Figure 5) at both time points, indicating that detected Aβ peptides predominantly derive from the human APP transgene expression or reflecting the low level of endogenous rodent Aβ [51].

To examine whether lethal toxin modulated JAK2 and / or STAT3 signaling, we next treated MNK - 3 cells with lethal toxin for 2 hr, stimulated with IL - 23 for the indicated time and then examined JAK2 and STAT3 phosphorylation by western blot analyses.

Western blot analysis showed that phosphoinositide - dependent protein kinase 1, the upstream kinase that phosphorylates Akt, and several phosphatases (phosphatase and tensin homolog deleted on chromosome 10, protein phosphatase 1, and protein phosphatase 2A), known as negative regulators of the PI3K / Akt signaling pathway, were unchanged upon VPA treatment (Supplemental Fig. 4E), indicating that VPA might act on Akt directly.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

I'm not suggesting you either reject as faulty any particular sets, rather that you indicate how your choice adds to the signal rather than the noise, as has been done with other reconstructions in the analysis contained in the papers above.

Although the Board went out of its way to indicate that its analysis was case - specific and that the outcome does not entail that all private or public employee benefit plans are required to cover the cost of medical cannabis, one can not help but feel that this decision is in fact precedent setting and may signal the opening of the floodgates for similar complaints to be made across the country.

The Institute is already the only SETI group that performs real - time analysis of its collected signals, using fast Fourier transform to look for narrow - band carrier signals that would indicate a non-natural source.