Sentences with phrase «signalling mechanisms underlying»
«Overall, our data suggest that a novel signaling mechanism underlies the transformation of proneural glioma stem cells to mesenchymal - like cells and their maintenance as stem - like cells,» Nakano says.
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It is expected that the molecular mechanisms underlying the inhibition of interferon signal transduction by C proteins would then be fully identified.
«These findings reveal a unique fulvestrant signaling process involving the increased regulation of hsa - miR - 765 that suppresses the HMGA1 protein as part of the mechanism underlying the tumor suppressor action in prostate cancer.
Moreover, small amounts of singlet oxygen produced during metabolic reactions can act as a local signaling factor that oxidizes and modifies target molecules, but the underlying mechanisms are poorly understood.
Now, they have isolated the mechanism underlying healthy development, which has provided new insights into what type of embryo movement is important and the specific signals that are needed to make a healthy joint.
Marijuana, like other drugs of abuse, stimulates brain dopamine (DA) signaling in the nucleus accumbens (1, 2), which is a mechanism believed to underlie the rewarding effects of drugs (3 ⇓ — 5) and to trigger the neuroadaptations that result in addiction (reviewed in ref.
Dr. Shanker's expertise, leadership, and motivation to structure and direct the current research will uncover underlying mechanisms of lymphocyte crosstalk, along with their interface with neural signaling.
The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.
Understanding the underlying mechanisms allows identifying putative sites for pharmacological intervention and opens the prospect of engineering artificial molecular switches derived from the highly efficient systems that have evolved for cellular signal transduction.
Objective: To use innovative approaches of integrative biology to unravel how lymphocytes process an array of molecular signals arising from contact with dendritic cells, thereby better understanding the mechanisms that underlie immunity and how they are altered in disease states.
The Neurophysics Group has the objective to study physical mechanisms underlying signal perception and transduction in the nervous system and to apply experimental physics methods to problems in neuroscience.
The goal of this study is to unravel the molecular mechanisms underlying the dive response, specifically, to study a signaling pathway that coordinates local blood flow.
The advanced understanding of the mechanisms underlying Oligophrenin1 - related ID, allowed us to develop a therapeutic approach targeting the RHOA / ROCK signalling pathway and repurpose Fasudil - a well - tolerated ROCK and PKA inhibitor - as a treatment of ID.