Sentences with phrase «significant effect of treatment»

Significant effect of treatment, time and interaction (all P < 0.01).

Primary efficacy analysis revealed a significant effect of treatment on the proportion of remitters (14.1 % active rTMS and 5.1 % sham)(p = 0.02).

The data were statistically analyzed by two - way ANOVA using age and source of inoculation as the variables, and the results show a highly significant effect of the treatment (P < 0.001), but no significant effect on the interaction among the variables.

Not exact matches

This test confirmed a significant positive effect of treatment on investment in high variance stocks, both for the cortisol administration study (z = 2.37, P = 0.018) and the testosterone administration study (z = 2.04, P = 0.041, see Fig.

However, significant concerns exist regarding unknown fetal effects, as well as risk of relapse and treatment dropout with subsequent return to opioid use and risk of overdose (64).

However, we noted that the introduction of nonbreastfeeding at 1 y, when the children were 15 mo old, was a significant main effect of the D treatment because 4 women who had not received the D treatment were still providing breastfeeding with complementary foods.

Put simply, the beta blocker effect was significant before the advent of this improved treatment, but the beneficial effect has since disappeared.

«A significant body of research has resulted in a shift from thinking of placebos as just «dummy» treatments to recognizing that placebo effects encompass numerous aspects of the health care experience and are central to medicine and patient care,» said the article's coauthor Ted Kaptchuk, Director of the Program in Placebo Studies at Beth Israel Deaconess Medical Center (BIDMC) and Professor of Medicine at Harvard Medical School.

«We measured many aspects of social ability and found significant treatment effects on social cognition, social interaction and social communication in youth with autism,» Corbett said.

Heat treatment after an injection of traditional iron oxide nanoparticles had no significant effect on the tumors.

Results showed that the lifestyle intervention had no significant effect on healthy live birth rate and overall live birth rate in any of the six subgroups having fertility treatment.

While the treatment did have some favorable effects, in the main measure of outcome — measured with a cognitive test called the Alzheimer's Disease Assessment Scale - cognitive subscale — the researchers did not observe any statistically significant benefit compared with placebo.

The successful treatment of certain physical and psychological complaints can be explained to a significant extent by the placebo effect.

Researchers trying out new treatments need to make sure any effect the treatment has in reducing the incidence of heart disease is statistically significant.

«Just like their matriarch, the Lacks family continues to have a significant impact on medical progress by providing access to an important scientific tool that researchers will use to study the cause and effect of many diseases with the goal of developing treatments,» said NIH Director Francis S. Collins, M.D., Ph.D..

«Most antibiotics have their effect, directly or indirectly, by causing damage to bacterial DNA, so finding ways to cripple DNA repair would represent a significant advance in the treatment of resistant infections,» says senior study author Evgeny Nudler, PhD, the Julie Wilson Anderson Professor of Biochemistry, Department of Biochemistry and Molecular Pharmacology, NYU Langone.

The statistical model used (network meta - analysis) is not suitable, as it can lead to an incorrect evaluation of treatment effects: Non-significant differences can incorrectly appear to be significant.

«Finally, analysing the transcriptional effect of the topical immunotherapies used for the treatment of mouth ulcers in SLE, we found a significant differential expression of VEGF pathway genes,» Dr Julià concluded.

The side - effects of these treatments can be significant, so current research is focused around precision medicine — classifying patients on their tumor's molecular changes, and only giving them the treatments that are expected to be most effective.

«But given the significant side - effects previously associated with treating the disease, notably fatigue and neuropsychiatric side effects, we were interested in looking at the impact of new treatments on patients» ability to work, and in a broader sense, how this effects employers and overall economies.»

However, because the a4 * receptor subunit is important for learning, memory, appetite, and biological clock timing, treatments that narrowly target a4 * receptors could cause significant side effects, says Daniel McGehee, a neurobiologist at the University of Chicago.

J147 treatment also resulted in a significant effect on Aβ metabolism, reducing levels of soluble Aβ without an effect on plaque density or size (Figure 2).

Therefore, while treatment with J147 enhanced the cognitive ability of the huAPP / PS1 mice, it had no significant effect on plaque load but produced a significant reduction of soluble Aβ levels.

Men with low - risk prostate cancer who previously had to choose between aggressive treatment, with the potential for significant side effects, and active surveillance, with the risk of disease progression, may have a new option.

These combined neuroprotective and memory enhancing effects of a single molecule suggest that J147 has significant potential for the treatment of AD.

The failure in pancreatic cancer treatment is main due to the presence of a dense and poorly vascularized stroma that increase the drug clearance in the tumors rather than the healthy tissues, decreasing drug bioavailability in the target tissue and leading to significant side effects.

A significant effect was found in the treatment group; no persistent effect was seen in the treatment cohort that had booster sessions of mSMT.

Yet, most patients continue with the expensive treatment — despite the possibility of significant side effects — because they and their doctors fear the condition will worsen if they stop, Koltun explained.

Although effective in the treatment of anxiety, they can cause significant side effects, including orthostatic hypotension (drop in blood pressure on standing), constipation, urinary retention, dry mouth, and blurry vision.

Analysis of escape latencies (Figure 3B) during training indicated significant effects of aging and, possibly, rapamycin, such that escape latencies were increased in aged mice and were decreased by rapamycin treatment (P = 0.0021, P = 0.0548, and P = 0.2419 for age, treatment, and age / treatment interaction, respectively, 3 - way ANOVA with age and treatment as between - subjects factors and training day as within - subjects factor).

No significant effects of either exercise or oil treatments were observed on lean mass.

Thus far, at therapeutic concentrations, no significant side effects of the treatment with TA were obvious.

There was a significant score reduction (42.5 %) of the MMDQ as the main effect parameter; however, symptoms gradually returned after treatment ended.

In a study that evaluated the effects of testosterone therapy on cognition, neuropsychiatric symptoms and quality of life in male patients with Alzheimer's disease and healthy elderly men, patients receiving testosterone had significant improvement in quality - of - life scores and the treatments were well tolerated.

Together with partial response (useful benefit but still some significant complaints), the positive effect of the treatment increased to 65 - 68 per cent and 70 - 88 per cent respectively.

Effect of treatment, P < 0.0001; effect of time × treatment interaction, P < 0.0001 (both: repeated - measures ANOVA); all of the points differed significantly (P < 0.001) between treatments starting from the 6th hour (Tukey's honestly significant differences post hoc Effect of treatment, P < 0.0001; effect of time × treatment interaction, P < 0.0001 (both: repeated - measures ANOVA); all of the points differed significantly (P < 0.001) between treatments starting from the 6th hour (Tukey's honestly significant differences post hoc effect of time × treatment interaction, P < 0.0001 (both: repeated - measures ANOVA); all of the points differed significantly (P < 0.001) between treatments starting from the 6th hour (Tukey's honestly significant differences post hoc test).

It is a much safer treatment option than minoxidil and finasteride both of which have significant side effects.

A 2012 study from Diabetes Care, however, found that 24 months of treatment with benfotiamine had no significant effects on peripheral nerve function or markers of inflammation in participants with type 1 diabetes.

Supplementation of the diet with glutamine or glutamic acid prior to treatment with indomethacin produced significant amelioration in all the effects produced by the drug in the small intestine (P < 0.001 for all the parameters measured).

One study, focusing on castor oil's effects on our lymphatic system, found a «significant» increase in the number of T - 11 cells within patients after performing a castor oil treatment.

In case of a significant interaction, paired - samples t tests were performed to determine training effects within treatment groups or within types I or II fibers.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.

- Patient in need of significant lifestyle changes (e.g. diet, exercise, sleep, stress management)- Patient is self - prescribing supplements, herbs, vitamins or natural therapies - Patient interested in natural approach to ailment - Natural Medicine Consult / Patient not progressing with current treatment - Adjunctive / supportive therapy needed for continuation of conventional treatment / side effect reduction

Taking the treatment effects at face value, treatment schools in Houston would rank third out of twelve in math and fifth out of twelve in reading among charter schools in NYC with statistically significant positive results in the sample analyzed in Dobbie and Fryer (2011b).

The therapeutic dotential of dietary precursor modulation by a fish - oil - supplemented diet (n - 3 fatty acids), such as eicosapentaenoic acid (C20: 5,n - 3) and docosahexaenoic acid (C22: 6,n - 3) in the therapy of ulcerative colitis has been shown to result in a 35 % to 50 % decrease in neutrophil production of LTB4.28 Significant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fSignificant improvement in symptoms and histologic appearance of the rectal mucosa has been observed in several small series of patients with Crohn's disease and ulcerative colitis given fish oil at 3 to 4 g daily for 2 to 6 months in uncontrolled studies.29 However, a larger, randomized, double - blind trial comprising 96 patients with ulcerative colitis failed to reveal any benefit in remission maintenance or treatment of relapse on 4.5 g of eicosapentaenoic acid daily, despite a significant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fsignificant reduction in LTB4 synthesis by blood peripheral polymorphonuclear cells.30 It should be emphasized, however, that the anti-inflammatory actions of the fish oils, in addition to inhibition of LTB4, include suppression of IL - 1 and platelet activating factor synthesis and scavenging of free oxygen radicals.30 The impact of increased lipid peroxidation after fish oil supplementation should be considered when altering the n - 6: n - 3 fatty acid ratio.31 Antioxidant supplementation may be able to counteract the potentially adverse effects of n - 3 fatty acids.

The other good news is that these dogs have very few heartworms present, as evidenced by the fact that none of them have had any significant side - effects of treatment.

We used a 2 - way analysis of variance (ANOVA) and Tukey honestly significant difference (HSD) tests to determine the effects of sex and reproductive status (treatment = intact versus sterilized) on the areas of the home ranges occupied by our study animals during the breeding and nonbreeding seasons.

Treatment and Prevention Although there are some therapies that have been shown to decrease the amount of FeLV in the bloodstream of affected cats, these therapies may have significant side effects and may not be effective in all cases.

This demonstrates that there is significant waste in the treatment of fossil fuels that will disappear when a price signal for wasting the resource is sent to consumers; further, we know there are significant and readily available alternatives for energy to energy derived from burning carbon, and when the price is made clear and fair, the preference for these alternatives is amply illustrated in the Market; from these two effects we see that the Law of Supply and Demand is relevant to the pricing of CO2E, and not monopolistic pricing.

My results showed significant beneficial side effects that increased the effectiveness of medical based treatments by 60 %.