Sentences with phrase «sip1 oligomers»

The nature of the bonds that stick the BPA molecules together doesn't allow the oligomers to revert to BPA.

Most importantly, extensive studies by Collins and his collaborators found that the oligomers are themselves not harmful.

TAML treatment at this pH caused BPA to assemble into larger units called oligomers, which clump together and precipitate out of the water.

According to Collins, the oligomers could be filtered and disposed of in a BPA water treatment facility.

To ensure the safety of the decontaminated water, including the oligomers, the researchers tested it with Tiered Protocol for Endocrine Disruption (TiPED) assays.

In contrast with pH 8.5 treatment, the BPA molecules were destroyed and no oligomers were detected.

To investigate the nonlinear response of such plasmonic oligomers, the authors used a novel optical microscopy technique, which is equipped with polarization - structured beams.

The oligomers were fabricated at the University of Tübingen.

Joint research between Tampere University of Technology (TUT)(Finland) and University of Tübingen (Germany) has shown that carefully structured light and matching arrangements of metal nanostructures (so - called «plasmonic oligomers») can be combined to alter the properties of the generated light at the nanometer scale.

a) Plasmonic gold oligomer consisting of nanorods that are azimuthally arranged.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

While these compounds did not reduce the amount of protein aggregates, they were found to reduce the protein's toxicity and to increase the stability of amyloid fibrils — a finding that lends further evidence to the theory that smaller assemblies of amyloid - beta known as oligomers, and not the fibrils themselves, are the toxic agents responsible for Alzheimer's symptoms.

In Ferris's lab, Hébrard conducted research on the formation of RNA oligomers — potential precursors of life — on clay minerals believed to be present on the primitive Earth.

The resin attracts the oligomers to a greater or lesser extent depending on their acidity, causing the compounds to pass through the column at different speeds.

The new process developed by the team, in collaboration with Dr Julien Poly from the Institut de Science des Matériaux de Mulhouse, France, is called «vinyl oligomer combination».

Research by Finch's team in the mid -»90s also led to a startling discovery in Alzheimer's research: In 1998, working with neuroscientists at Northwestern University in Evanston, Illinois, the group reported that amyloid — the insoluble protein that piles up in the Alzheimer's - afflicted brain — is also highly neurotoxic when it clusters into small but soluble oligomers, dubbed ADDLs.

However, when temperature is then decreased, type - I collagen remains a fibrillar hydrogel, whereas CMA will disassemble into triple helices or short oligomers and return to a suspension.

The intervening sequence RNA excised from the ribosomal RNA precursor of Tetrahymena forms linear and circular oligomers when exposed to a heating - cooling treatment in vitro.

An oligomer of the Sec61 trimeric complex is thought to form the protein - conducting channel for protein transport across the endoplasmic reticulum.

The actin then takes any CPEB oligomers that are around and activates them, which makes more actin and causes the formation of a self - replicating prion of the CPEB.

A purified yeast Sec61 complex bound to monomeric yeast ribosomes as an oligomer in a saturable fashion.

Moreover, a funnel - shaped pore in the Sec61 oligomer aligned with the exit of a tunnel traversing the large ribosomal subunit, strongly suggesting that both structures function together in the translocation of proteins across the endoplasmic reticulum membrane.

«The rotelle — technically called oligomers — are basically wrapped - up polymers,» Lupton says.

In the brains of patients with Alzheimer's, amyloid peptides aggregate to form oligomers and plaques that are thought to be responsible for the disease symptoms.

When, however, the pH value becomes acidic, the large oligomers dissociate and the protective protein is activated.

The antibody created at Northwestern binds to the toxic oligomers and could one day deliver therapies to the brain or help clinicians evaluate how a patient is responding to a new medication.

But these days most neuroscientists agree that a tiny particle form of the same protein, called an oligomer, is the primary toxin in the illness.

When this happens, molecular nutrients can no longer move to where they are needed and the oligomers produce toxic effects leading to the eventual death of the brain cells.

Their markers light up if an additional oligomer that bridges the two halves binds to both, which only occurs when they park next door to each other on the target.

Traditional methods for mapping HIV genetic material use long strings of these nucleotides, called oligomers, to find and bind to complementary strands of DNA or RNA in sample tissues.

But oligomers are large and somewhat clumsy molecules, and they occasionally bind to cellular components other than the target sequence.

«Non-invasive imaging by MRI of amyloid beta oligomers is a giant step forward towards diagnosis of this debilitating disease in its earliest form,» said Dravid, the Abraham Harris Professor of Materials Science and Engineering at the McCormick School of Engineering and Applied Science.

Oligomers may appear more than a decade before plaques are detected.

Images demonstrate that Abeta oligomers (568 - NU4) are often associated with, yet distinct from, amyloid plaques (ThioS).

Brain sections from an aged Alzheimer's mouse model were probed with antibodies against Abeta oligomers (568 - NU4, red) and amyloid plaques (ThioS, green).

This new MRI probe technology is detecting something different from conventional technology: toxic amyloid beta oligomers instead of plaques, which occur at a stage of Alzheimer's when therapeutic intervention would be very late.

Data supports the notion that NU4 thus affords an excellent targeting antibody for the development of an amyloid beta oligomer - specific MRI probe that is distinct from currently available plaque probes.

Amyloid beta oligomers now are widely believed to be the culprit in the onset of Alzheimer's disease and subsequent memory loss.

The ability to detect amyloid beta oligomers, Klein said, is important for two reasons: amyloid beta oligomers are the toxins that damage neurons, and the oligomers are the first sign of trouble in the disease process, appearing before any other pathology.

These faces allow the proteins to snap together like magnets, forming long chains, or oligomers.

To recycle the skin, the device is soaked into recycling solution, making the polymers degrade into oligomers (polymers with polymerization degree usually below 10) and monomers (small molecules that can be joined together into polymers) that are soluble in ethanol.

Finally, that the onset of Alzheimer's disease coincides with immunosenescence, indicates that the immune system is constantly disposing of toxic oligomers while leaving plaque untouched, until due to its decline with age, the immune system is unable to remove those oligomers and the disease appears.

I personally won't get excited about that until its practitioners can do it for large oligomeric proteins — which includes being able to predict what kind of oligomer any given macromolecule will form — and can also predict how a macromolecule's conformation changes when substrate or another macromolecule binds to it.

And that sequence can form long chains called oligomers as well as fibers called fibrils.

He argues that if those oligomers and fibrils weren't needed, evolution would have eliminated them long ago.

Summary: Many of the steps are known in using glyoxal with hydrogen peroxide to form dicarboxylic acids and chains of hydrocarbons, known as oligomers.

These oligomers are also the starting materials for troubling atmospheric aerosols, known as secondary organic aerosols.

We discovered that levuglandins can greatly accelerate the oligomerization of amyloid beta and that the oligomers so formed are neurotoxic.

Collective Effects in Second - Harmonic Generation from Plasmonic Oligomers, Nano Letters (2018).

The CAMKK2 - AMPK kinase pathway mediates the synaptotoxic effects of Amyloid - beta oligomers through Tau phosphorylation on S262.