«
Small molecule inhibitor shows promise in precision cancer targeting.»
Not exact matches
Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin - 11 and is now working with Byers and Brenner to
show how the
molecule binds to Celebrex and other
small molecule drug cadherin - 11
inhibitors.
Finally, we
show that addition of
small molecule inhibitors of eIF2α dephosphorylation to muscle stem cell cultures permits their ex vivo expansion and engraftment into a preclinical mouse model of Duchenne muscular dystrophy.
Vescor, advised by its scientific founders White and Kimmelman, whose research has
shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop
small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.
The combined treatment of ActD with leptomycin B, a
small molecule nuclear export
inhibitor, has been
shown to successfully lead to the accumulation of transcriptionally active p53 in the nuclei of human papillomavirus positive cervical carcinoma cells, resulting in apoptosis of the cells [16].