Sentences with phrase «social defeat stress»

Our findings first confirmed previous work with this model in demonstrating that compared to undefeated control animals, mice most susceptible to social defeat stress demonstrated a number of abnormalities in social avoidance, depression and anxiety as measured by routine test procedures.

The Chronic Social Defeat Stress (CSDS) mouse model has received much interest recently as it closely mimics the dynamic range of individual responses to stressors such as the development of a major depressive disorder, anxiety, post-traumatic stress disorder or resil ¬ iency to these disease states.

At the same time, the rodents had an even greater response to social defeat stress than normal mice do, suggesting their brains also are more susceptible to a depressive - like state.

To demonstrate the effects of bullying, the researchers used an animal model simulating the physical and emotional stressors involved in human bullying — chronic social defeat stress.

Looking inside the brains of animals exposed to chronic social defeat stress, the scientists observed hyperactive firing of neurons in the ventral tegmental area (VTA), a critical part of a reward circuit.

Not exact matches

While the Huhman laboratory primarily uses inescapable social defeat to model the clinical psychopathologies (e.g., anxiety, posttraumatic stress disorder) that can result from bullying or abuse, researchers have also shown that exposure to escapable social defeat results in CD, albeit to a reduced degree.

Our goal in using this multifaceted model was two-fold 1) to confirm and further characterize the distinct behavioral traits in animals most susceptible to social stress after going through the 10 - day social defeat paradigm compared to undefeated control animals; 2) to provide pharmacological validation for this model using standard antidepressant medications such as fluoxetine and imipramine.

Specifically, our data with the CSDS model suggests that animals most susceptible to social stress after going through the 10 - day social defeat paradigm exhibit increased social avoidance behavior, anhedonia and potentiated fear responding to sound cues.

We have also found that control and defeated (stressed) Cbg ko mice show no difference in the social interaction test, while defeated WT mice reduce their interaction time when compared to unstressed WT mice.

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