Sentences with phrase «specific genes affect»

Specific genes affect the risk of leprosy, says Amos, which may drown out the subtler effects of relatedness.

Not exact matches

The study, which is published in the journal Molecular Psychiatry, describes a possible mechanism for how the gene variant produces clinical symptoms by affecting levels of specific proteins in the brain.

This led Pembrey to suspect that genes on the sex - specific X and Y chromosomes were being affected by epigenetic signals.

We have identified hundreds of genetic variations associated with autoimmune diseases that appear to affect the activity of genes in specific regions of the genome, pointing to biological pathways that may be involved in disease and which, ultimately, may be treatable with medication.»

As Saaïd Safieddine, CNRS Director of Research at the Institut Pasteur and co-senior author of the study with Prof. Christine Petit (head of the Genetics & physiology hearing unit at the Institut Pasteur), explains, «we have just shown that it is possible to partially correct a specific form of hereditary hearing loss accompanied by balance problems using local gene therapy performed after the embryogenesis of the ear, which is primarily affected by the mutation responsible for the disorder.

What's different about Church's machine is that it can target the genes that affect a particular characteristic and alter them in specific ways.

New evidence from animal studies supported by the National Institute of Mental Health suggests that a specific gene may affect learned fearfulness.

«U1 dysfunction might produce changes in RNA processing affecting many genes or specific changes affecting a few key genes that are important in Alzheimer's,» Lah says.

The findings highlight specific sets of genes and the brain cells they affect as being involved in regulating anxiety.

Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte - specific regulatory regions near DDB1 / TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

His specific mutation subtly affects the slicing of the gene and doesn't affect the amino acid sequence that synthesizes the ZAP70 protein.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Future studies, she says, may be able to shed light on specific genes that affect academic achievement, which could help diagnose or treat learning disabilities.

A team including researchers from Rensselaer Polytechnic Institute have discovered that a specific gene may play a major role in the development of a life - threatening birth defect called congenital diaphragmatic hernia, or CDH, which affects approximately one out of every 3,000 live births.

It's no longer a matter of how genes affect the body but of how genes affect specific parts of the body.

During development, chromosomes are subject to chemical changes that don't affect the nucleotide sequence but can turn genes on or off; the best known example is methylation, in which a methyl group is attached to specific DNA regions.

Since proper functioning of the fat body is essential for the development of the female reproductive system after a blood meal, identifying which miRNAs are important to fat body functions, and what specific genes they target, can help design ways to manipulate the levels of microRNA or their targets, affect their interactions, disrupt mosquito reproduction, and thus prevent the spread of diseases the mosquitoes transmit.

Also, unlike chemical manipulators that diffuse throughout a cell, light can be applied to specific genes without affecting other parts of the cell.

Their goal is a database that will help them examine how specific gene variants affect health.

When they screened the KE family to see if some carried a defect in this gene, all affected members turned out to share a specific mutation that apparently rendered FOXP2 inactive, the group reports in the 4 October issue of Nature.

Ishii and his team chose to focus on two histone variants named TH2A and TH2B, known to be specific to the testes where they bind tightly to DNA and affect gene expression.

«But genes tied to autism tend to affect specific functions, such as the connections between brain regions that are essential to many human - specific behaviors, like speech and language.»

«Mutations in epilepsy tend to affect specific areas of the gene, whereas mutations associated with intellectual disability are more often distributed throughout the entire gene.

«Originally, we wanted to establish a disease model for FOP that might help us understand how specific gene mutations affect bone formation,» said first author Yohei Hayashi, PhD, a former postdoctoral scholar in Yamanaka's laboratory.

Now I am trying to understand the specific mechanism by which these genes affect CD1d dependent antigen presentation.

These mice are also primed for RNA interference from birth, so when the time comes — be it after the onset of the disease, or prior to — the team can turn off a specific gene to see how the loss of its function affects diabetes or the risk of diabetes.

«Originally, we wanted to establish a disease model for FOP that might help us understand how specific gene mutations affect bone formation,» said first author Yohei Hayashi, PhD, a former postdoctoral scholar with Yamanaka's laboratory.

But rather than changes in doublesex itself, these studies revealed changes in downstream targets of dsx, via changes to specific DNA sequences to which DSX protein binds in the cis - regulatory regions of the bric - a-brac and desatF genes and affecting sex differences in abdominal pigmentation and pheromone production.

The activated AHR / NuRD complex altered the expression of differentiation - specific genes that control the first two developmental decisions without affecting the pluripotency program.

June 4, 2015 New tool brings standards to epigenetic studies One of the most widely used tools in epigenetics research — the study of how DNA packaging affects gene expression — is chromatin immunoprecipitation (ChIP), a technique that allows researchers to examine interactions between specific proteins and genomic regions.

This affected stage - specific gene expression, downregulation of the entire chromosome 31, and upregulation of gene arrays on chromosomes 5 and 8.

However, gene variations, the presence of strain - specific genes, and the occurrence of plasmids in strain GP59 could affect the expression pattern of these common genes.

By affecting the rate of cell differentiation and gene expression, thyroid hormones regulate the growth and migration of neurons, including synaptic development and myelin formation in specific brain regions.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

They do not kill cancerous or viral cells, but regulate the action of specific genes that control the production of cellular proteins that affect cell growth.

Multiple studies have found parallels in brain structure and even identified specific gene analogues when comparing affected humans and canines.

Yes, epigenetics, which literally means «upon genetics,» can affect the way genes are expressed, not always in a parent - specific manner.

Not enough is known yet about the prevalence of the specific gene in the affected breeds to be able to breed out the condition, but it's a start.

Understanding what happened to the genes of the dog as it evolved, and the genetic differences between the breeds, will provide information that may enable intervention in some of the breed - specific health problems that continue to affect the welfare of many dogs.

This ensures that if a potential breeding dog is a carrier of a specific disease - carrying gene that safety measures are put in place to prevent producing puppies affected by it.

Lower activity of a specific gene may affect a person's social behavior, including the ability to form healthy relationships, researchers say.