Sentences with phrase «stat3 signaling cascades»

When mutated, BRAF, an enzyme that acts in a signaling cascade known as the MAPK / ERK pathway, becomes overactive and leads to increased cellular growth, a hallmark of cancer.

The structure of CX3CR1 includes a domain known as Helix 8, which is important for initiating a signaling cascade.

When they react to external stimuli, by binding molecules, for example, a structural transformation takes place on the inside that triggers a signalling cascade (see 2012 Nobel Prize in Chemistry).

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cells.

«In the case of glycoprotein hormone receptors, the family of proteins that includes the thyroid receptor, upon binding of the extracellular hormone, the intramolecular activator (p10) induces structural changes of the receptor protein, triggering activation of the intracellular signaling cascade.»

Scientists at the University of Bonn and the Hebrew University of Jerusalem (Israel) have decoded a central signal cascade associated with epileptic seizures.

The molecule is known as a G protein - coupled receptor because it triggers so - called G proteins to bind to the inner side of a receptor and start a signal cascade.

Bohn noted isoquinolinone 2.1 is one example of a new class of «biased» kappa agonists that avoid many central nervous system side effects by preferentially activating a G protein - mediated signaling cascade without involving another system based on β - arrestin protein interactions.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

Research led by Margery Smelkinson found that NS1 modulates the activitiy of a signaling cascade known as the Hedgehog pathway (so named because fruit fly larvae lacking the Hedgehog gene emerge hairless and resemble tiny hedgehogs).

«The androgen signaling cascade is important for understanding early and late - stage prostate cancer progression.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

Researchers found that estrogen upregulates, and progesterone downregulates most of the same signaling cascade stimulated by MSH.

The researchers also tested whether learning and memory deficits could be corrected using drugs that calm the overactive signaling cascades.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

The result did not come as a total surprise because other worm genes that play a role in agingsuch as daf - 2are part of the same signaling cascade.

The scientists» model looks at the EGFR signaling cascade to investigate crosstalk between EFGR signaling and EMT in cell culture models of human breast epithelium.

Now, the research group led by Professor Koji Yamanaka at Nagoya University revealed that deficiency of the innate immune adaptor TRIF, which is essential for certain Toll - like receptor (TLR) signaling cascades, significantly shortened survival time of ALS mice.

The anti-apoptotic effect of BES was dependent on the activation of the PI3K / Akt signaling cascade and an increase in brain - derived neurotrophic factor (BDNF) production.

«It sounds paradox that for inhibiting an inflammation, a signalling cascade is needed that usually has a pro-inflammatory effect.

Removal of the phosphates by PTP - 1B should therefore turn off the signal cascade, and that's what researchers had found in the test tube studies.

For a long time, scientists were convinced that GPCRs influence the activity of the cell via activation of various intracellular signalling cascades while sitting at the cell surface.

The team discovered that the pain signals from a peripheral injury combined with subsequent morphine treatment worked together to cause a glial cell signaling cascade.

Rutin functions as a cold mimetic through activating a SIRT1 - PGC1α - Tfam signaling cascade and increasing mitochondrial number and UCP1 activity in BAT.

As soon as the calcium level exceeds a particular threshold value over a longer period of time, a signal cascade is triggered that initiates production of the body's tanning pigment melanin in the genetically modified cells.

The megakaryocyte / platelet - specific enhancer of the a2b1 integrin gene: Two tandem AP1 sites and the mitogen activated protein kinase signaling cascade.

Byron B. Goldstein was recognized for his contributions in the field of mathematical immunology and cell biology, specifically in modeling cell signaling cascades, pursuing cutting - edge research in cell activation, cell - signaling, cell surface receptor - ligand interactions, and the generation of allergic responses.

T. gondii has the capacity to modulate host signaling cascades and remodel its host cells» transcriptomes and proteomes profoundly.

Detailed biochemical and sophisticated imaging experiments are employed to delineate the molecular signaling cascades that couple receptors to the translational apparatus during long - lasting synaptic plasticity in the hippocampus, amygdala, cortex, and striatum, and whether these types of translational control are required for memory formation, social behaviors, and behavioral flexibility.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

Moreover; in addition to the various mutations that have been highlighted and interact in key component of signaling cascades, different types of RNAs have been shown to be involved in melanoma pathogenesis such as: miRNAs and lncRNAs [48, 49].

The NAADP antagonist partially inhibited oxytocin induced contraction, proving that well established Gq - protein - coupled oxytocin receptor does not solely activate IP3 signalling cascade but also through NAADP signalling.

The BMP protein acts as an activator for cell — surface receptors, and initiates cellular processes and signaling cascades.

Arginine stimulates proliferation of ovine trophectoderm cells through MTOR - RPS6K - RPS6 signaling cascade and synthesis of nitric oxide and polyamines.

Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen - activated protein kinase signaling cascades.

When TLR2 binds Mycoplasma, it kicks off a signaling cascade that results in NF - kappaB activation.

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

Rho family GTPase inhibition reveals opposing effects of mitogen - activated protein kinase kinase / extracellular signal - regulated kinase and Janus kinase / signal transducer and activator of transcription signaling cascades on neuronal survival.

In the past decade we have identified diverse signaling cascades that converge on gephyrin scaffold to regulate its scaffolding property, and in turn GABAergic neurotransmission.

Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase - 3β and a caspase -9-dependent apoptosis in cerebellar granule neurons.

Previously in a mutated BRAF mouse model, ablation of PTEN led to melanoma development [45], suggesting the PI3K / AKT signaling cascade is one of the critical players in melanoma turmorigenesis.

In particular, the cAMP signaling cascade directs adaptive cellular responses to a variety of stress stimuli via a combination of acute affects arising from GS - protein coupled receptor (GPCR)- mediated activation of PKA and long - term affects resulting from transcriptional reprogramming directed by CREB and the CREB Regulated Transcription Coactivators (CTRCs).

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

ADAMTS1 and MMP1 proteolytically engage EGF - like ligands in an osteolytic signaling cascade for bone metastasis

Our laboratory has spent many years delineating the regulation of translation initiation by the mTORC1 and ERK signaling cascades during LTP, LTD, and memory formation in the hippocampus.

Also mentioned here is that there is a key signaling cascade, which I've already mentioned the JAK / STAT pathway that regulates signaling.

STAT3 is a major adaptor, or actually it's a transcription factor that's activated by JAK2 kinase, and this leads to a so - called leptin signal, and the leptin signaling cascade.

So, as you can see, this insulin signaling cascade, at least on this arm, regulates a number of aspects of metabolism; both carbohydrate and synthesis carbohydrate metabolism, as well as protein synthesis and metabolism.

Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.

We further extended our analysis of pluripotency gene expression to a much larger scale to potentially identify similar signaling cascades that might be conserved between hNSCs and hESCs.