Sentences with phrase «stem cell marker for»

Review of «In Vitro Cell Motility as a Potential Mesenchymal Stem Cell Marker for Multipotency» from Stem Cells TM by Stuart P. Atkinson

Not exact matches

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

Three of the four projects receiving CIRM money capitalize on Victoria's expertise at finding markers for differentiated stem cells versus cells that still have tumor - forming potential.

Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development from embryonic tissue.

Researchers at Karolinska Institutet have identified cell surface markers specific for the very earliest stem cells in the human embryo.

«We've not had cell surface markers for the different stem cell states before, which has made it hard to study them,» says Fredrik Lanner, assistant professor at Karolinska Institutet's Department of Clinical Science, Intervention and Technology.

Coxsackie B virus (red) infects cells positive for the heart stem cell marker Sca - 1 (green).

This biomechanical marker could be used as a rapid and cost - effective approach to enrich for stem - like cells in corneal transplant tissue.

«In combination with recent advances in sorting cells on a biophysical basis, the biomechanical stemness markers we identified hold the potential to rapidly generate corneal transplants with highly enriched stem cell populations, which could one day translate into better outcomes for these patients.»

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

For example, labeling of these cells with stem - like cell associated markers (p63, nestin, and telomerase) have heavily implicated these cells as stem cells [13].

However, we have found a fluorescent marker for nestin, a neural crest stem cell marker, in the posterior limbal region of the human anterior segment in the vicinity of both the trabecular meshwork and Schwalbe's line (unpublished).

Expression of the Wnt inhibitor Dickkopf - 1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

Methods: Human corneas with attached scleral rims were obtained from eye banks and were assayed for telomerase activity and BrdU (bromodeoxyridine) incorporation to determine, respectively, the presence of a stem - like cell marker and replicative activity.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

Telomerase activity has been considered to be a marker for stem cells [23], but it is not found in all stem cell tissues [24].

Asialoglycoprotein receptor 1 is a specific cell - surface marker for isolating hepatocytes derived from human pluripotent stem cells.

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

However, as demonstrated by a recent report from Stuelten and colleagues [13], the complexity of CSC markers continues to pose challenges for identifying and isolating the putative tumor stem cell populations by the cell - sorting approach.

Support to date for the existence of an hypoxic niche in marrow blood stem cells came from indirect evidence such as expression of the hypoxia protein Hif - 1 and related genes and staining with surrogate markers of hypoxia.

Sophisticated cell targeting systems such as the gene therapy approach developed for senescent cell clearance by Oisin Biotechnologies could also be turned to stem cell or immune cell destruction, given suitable markers of cell chemistry.

Finally, within the fractionated cell populations, there was evidence for coexpression of lineage specific markers alongside of pluripotency genes, similar to lineage priming described first in hematopoietic stem cells [15].

She plans to test whether or not molecules designed to target the marker can block the signaling necessary for maintaining the cells» stem - like properties, which could lead to new antibody - based immunotherapies for breast cancer.

Oct - 4 is most consistently expressed of the pluripotency genes that we have studied, and it is switched off only in populations that have lost other measurable features of pluripotency, such as stem cell surface marker expression and the capacity for self - renewal.

Immunocytochemical staining for Ki67 (cell proliferation marker), Sox2 (neural stem cell marker), Olig2 (progenitor cell marker), and GFAP (glial fibrillary acidic protein, a marker for differentiated astrocytes) captured by confocal microscopy imaging.

Even more profound was a drop in insulinlike growth factor 1 (IGF - 1), which is a biomarker for cancer growth, and an increase in stem cell production, which is a marker for regeneration of cells.

Improving Stem Cell Treatment Success Researchers will manipulate the expression of immune markers on stem cells to develop safer and more effective therapies for horses with musculoskeletal injurStem Cell Treatment Success Researchers will manipulate the expression of immune markers on stem cells to develop safer and more effective therapies for horses with musculoskeletal injurstem cells to develop safer and more effective therapies for horses with musculoskeletal injuries.

Researchers will manipulate the expression of immune markers on stem cells to develop safer and more effective therapies for horses with musculoskeletal injuries.