Sentences with phrase «studying cohesin»
Studying cohesin has, of course, not only academic value.
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«Now, through our new study, we show that lowering levels of a particular cohesin protein called Rad21 in embryonic zebrafish produces similar types of heart defects to those found in people with CdLS,» Associate Professor Horsfield says.
By only analysing DNA sequences that bind to cohesin, roughly one per cent of the genome, it would allow us to analyse an individual's mutations and make it much easier to conduct studies to identify novel harmful mutations,» Martin Enge concludes.
In previous studies, researchers proved in mice that genes of the meiotic cohesin complex produce various degrees of infertility in mice.
In the ESCs they studied, the scientists identified 197 Cohesin / CTCF - flanked loops that contain active genes and enhancers, and 349 loops that contain repressed genes.
Our ongoing studies demonstrate that the condensin and cohesin complexes are key molecular machines that organize the functional 3D genome structures.
More specifically, we have been studying the roles of the condensin and cohesin complexes in 3D genome organization in the fission yeast, mouse and human systems.
These studies demonstrate that the two important protein complexes, condensin and cohesin, are both essential for the assembly of the functional genome architecture, but their roles in the 3D genome organization (gene contacts and topological domain organization) are significantly different.