Sentences with phrase «subclones with»

Subclones with the best evolutionary fitness will, in time, come to dominate the population.

Not exact matches

But tumors from patients with distant metastases to the lung and liver showed massive epigenetic changes that mapped to large, blocklike segments of the genome, both in the distant metastases themselves and in the section, or «subclone,» of the primary tumors they came from.

By labeling the different subgroups with fluorescent dyes, researchers determined that just one of the subclones was responsible for the disease metastasis.

These findings reinforce many things that we already know: that mutations acquire gradually with age, that most of the mutations in AML (and likely other tumors) are random background events not contributing to tumorigenesis, and that subsequent mutation and evolution can give rise to subclones that ultimately determine cancer progression and response to therapy.