Sentences with phrase «subsequent increases of»

Subsequent increases of the dose offer little or no benefit as the medication pushes the energy machinery into overdrive.

The worldwide decline in breastfeeding and the subsequent increase of artificial feeding with infant formula is an issue of major public concern.

Human - caused climate change has been occurring over the last 200 yr, largely because of the combustion of fossil fuels and subsequent increase of atmospheric CO2.

At the same time, the subsequent increase of waste takes an ecological perspective on a global scale.

Short - term longitudinal analysis also revealed an association between the depressive state and subsequent increase of the body weight.

Not exact matches

These risks and uncertainties include, among others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition from generic drug manufacturers; data from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.

And, if he thinks he will stay for five years, he has a positive net present value of $ 12,712, assuming he saves that $ 280 every month during the first year and increases savings by 3 % each subsequent year.

With unemployment falling steadily through the year, there has been less justification for crisis - era policy, and a sense among policymakers that they could balance the higher rates sought by «hawks» with a slow pace of subsequent increases.

Actual results, including with respect to our targets and prospects, could differ materially due to a number of factors, including the risk that we may not obtain sufficient orders to achieve our targeted revenues; price competition in key markets; the risk that we or our channel partners are not able to develop and expand customer bases and accurately anticipate demand from end customers, which can result in increased inventory and reduced orders as we experience wide fluctuations in supply and demand; the risk that our commercial Lighting Products results will continue to suffer if new issues arise regarding issues related to product quality for this business; the risk that we may experience production difficulties that preclude us from shipping sufficient quantities to meet customer orders or that result in higher production costs and lower margins; our ability to lower costs; the risk that our results will suffer if we are unable to balance fluctuations in customer demand and capacity, including bringing on additional capacity on a timely basis to meet customer demand; the risk that longer manufacturing lead times may cause customers to fulfill their orders with a competitor's products instead; the risk that the economic and political uncertainty caused by the proposed tariffs by the United States on Chinese goods, and any corresponding Chinese tariffs in response, may negatively impact demand for our products; product mix; risks associated with the ramp - up of production of our new products, and our entry into new business channels different from those in which we have historically operated; the risk that customers do not maintain their favorable perception of our brand and products, resulting in lower demand for our products; the risk that our products fail to perform or fail to meet customer requirements or expectations, resulting in significant additional costs, including costs associated with warranty returns or the potential recall of our products; ongoing uncertainty in global economic conditions, infrastructure development or customer demand that could negatively affect product demand, collectability of receivables and other related matters as consumers and businesses may defer purchases or payments, or default on payments; risks resulting from the concentration of our business among few customers, including the risk that customers may reduce or cancel orders or fail to honor purchase commitments; the risk that we are not able to enter into acceptable contractual arrangements with the significant customers of the acquired Infineon RF Power business or otherwise not fully realize anticipated benefits of the transaction; the risk that retail customers may alter promotional pricing, increase promotion of a competitor's products over our products or reduce their inventory levels, all of which could negatively affect product demand; the risk that our investments may experience periods of significant stock price volatility causing us to recognize fair value losses on our investment; the risk posed by managing an increasingly complex supply chain that has the ability to supply a sufficient quantity of raw materials, subsystems and finished products with the required specifications and quality; the risk we may be required to record a significant charge to earnings if our goodwill or amortizable assets become impaired; risks relating to confidential information theft or misuse, including through cyber-attacks or cyber intrusion; our ability to complete development and commercialization of products under development, such as our pipeline of Wolfspeed products, improved LED chips, LED components, and LED lighting products risks related to our multi-year warranty periods for LED lighting products; risks associated with acquisitions, divestitures, joint ventures or investments generally; the rapid development of new technology and competing products that may impair demand or render our products obsolete; the potential lack of customer acceptance for our products; risks associated with ongoing litigation; and other factors discussed in our filings with the Securities and Exchange Commission (SEC), including our report on Form 10 - K for the fiscal year ended June 25, 2017, and subsequent reports filed with the SEC.

Among the factors that could cause actual results to differ materially are the following: (1) worldwide economic, political, and capital markets conditions and other factors beyond the Company's control, including natural and other disasters or climate change affecting the operations of the Company or its customers and suppliers; (2) the Company's credit ratings and its cost of capital; (3) competitive conditions and customer preferences; (4) foreign currency exchange rates and fluctuations in those rates; (5) the timing and market acceptance of new product offerings; (6) the availability and cost of purchased components, compounds, raw materials and energy (including oil and natural gas and their derivatives) due to shortages, increased demand or supply interruptions (including those caused by natural and other disasters and other events); (7) the impact of acquisitions, strategic alliances, divestitures, and other unusual events resulting from portfolio management actions and other evolving business strategies, and possible organizational restructuring; (8) generating fewer productivity improvements than estimated; (9) unanticipated problems or delays with the phased implementation of a global enterprise resource planning (ERP) system, or security breaches and other disruptions to the Company's information technology infrastructure; (10) financial market risks that may affect the Company's funding obligations under defined benefit pension and postretirement plans; and (11) legal proceedings, including significant developments that could occur in the legal and regulatory proceedings described in the Company's Annual Report on Form 10 - K for the year ended Dec. 31, 2017, and any subsequent quarterly reports on Form 10 - Q (the «Reports»).

The report estimates that for each 1 percent of shoppers who return for a subsequent visit, overall revenue will increase by approximately 10 percent.

Of course, detecting an increase in the number of mini flash crashes in stock markets prior to the start of a subsequent larger flash crash would show that mini flash crashes could have helped predict a larger flash crash, like tremors before an earthquakOf course, detecting an increase in the number of mini flash crashes in stock markets prior to the start of a subsequent larger flash crash would show that mini flash crashes could have helped predict a larger flash crash, like tremors before an earthquakof mini flash crashes in stock markets prior to the start of a subsequent larger flash crash would show that mini flash crashes could have helped predict a larger flash crash, like tremors before an earthquakof a subsequent larger flash crash would show that mini flash crashes could have helped predict a larger flash crash, like tremors before an earthquake.

In May, SolarCity rolled out a new loan offering and in each subsequent month the percentage of its business derived from purchases — cash and loans — has increased significantly.

Also subsequent to the close of the first quarter, WPX amended its credit facility resulting in an increase to total commitments from $ 1.2 billion to $ 1.5 billion; an increase to the borrowing base from $ 1.5 billion to $ 1.8 billion; and the maturity was extended to 2023.

The effect on Amazon has been equally significant: I detailed last year how the revelation of AWS» financial results was effectively a Facebook - level IPO, and subsequent earnings reports in which AWS has demonstrated the power of scale — increased revenue plus increased margins — have only solidified the fact that AWS will be a substantial driver of Amazon's revenue and (eventual!)

Although buyers are protected from taxes for years prior to their year of purchase, buyers may insure a tax increase for the current and subsequent tax years if the assessors discover omitted property.

As a result there was actually a relatively low rate of client redemptions, especially relative to the tech bubble of 2000, and importantly, clients participated in the subsequent increase in the value of their investment portfolios by staying invested as markets recovered.

Subsequent to the subprime meltdown in 2008, the activities of the shadow banking system came under increasing scrutiny and regulations.

The menu price increases by Dunkin' franchisees in anticipation of higher minimum wages, and subsequent negative consumer reaction, have come quickly.

The Board of Directors, upon the recommendation of the Compensation Committee, approved this increase in the base - year EPS in order to exclude the impact of the company's stock repurchase program on a prospective basis, thereby making subsequent adjustments of EPS in future years unnecessary for purposes of the FY2015 - FY2017 LTI plan.

Subsequent statements have seen some OPEC member countries canvassing the possibility of further quota increases, placing downward pressure on prices since early July.

Following the two increases in the cash rate at the end of 2003, the Board considered at its subsequent monthly meetings whether there was a case to increase rates further.

This started with the release of a strong March employment report, and was reinforced by the subsequent publication of other strong economic data and a relatively large increase in the CPI.

Incredibly Cheap: Subsequent to closing the Gilby acquisition, we estimate Point Loma's production will increase to 1,100 boe / day which equates to a flowing barrel value of $ 11,200 per boe / day versus the peer group of $ 20,000 to $ 40,000 per boe / day.

While the report does say that higher mortgage rates could cool things off later this year or early next year, it adds that «a flood of foreclosures, and subsequent sharp supply increases, is simply not in the cards.»

«Although extensive choice seems appealing, research shows that it may hinder motivation to buy and decrease subsequent satisfaction with purchased goods... Using data from nearly 800,000 employees, we tested the hypothesis that employee 401 (k) participation rates fall as the number of fund options increase.

Examples of these risks, uncertainties and other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and other international events; the risks and increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or other disturbances to our information technology and other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology; amendments to our collective bargaining agreements for crew members and other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.

Yet, the past few U.S. recessions have led to subsequent federal debt increases to help bring the country out of recession.

Epidemiologists have found that when the incarceration rate rises in a county, there tends to be a subsequent increase in the rates of sexually transmitted diseases and teenage pregnancy, possibly because women have less power to require their partners to practice protected sex or remain monogamous.

There is no evidence for significant increase of CO2 in the medieval warm period, nor for a significant decrease at the time of the subsequent little ice age.

Consider a partial list of developments since just World War II: a broad national decline in denominational loyalty, changes in ethnic identity as hyphenated Americans enter the third and subsequent generations after immigration, the great explosion in the number of competing secular colleges and universities, the professionalization of academic disciplines with concomitant professional formation of faculty members during graduate education, the dramatic rise in the percentage of the population who seek higher education, the sharp trend toward seeing education largely in vocational and economic terms, the rise in government regulation and financing, the great increase in the complexity and cost of higher education, the development of a more litigious society, the legal end of in loco parentis, an exponential and accelerating growth in human knowledge, and so on.

The main current of subsequent homiletical theory, however, has exalted narrative at the expense of induction, despite increasing discontent with narrative as a theological category.

In this perspective, and in view of all subsequent Jewish history, it is not difficult to understand why Esther was accorded a place of increasing prestige in Judaism until it came to be known not simply as one of the megilloth (plural, «scrolls») but the megillah (sing.)

In the subsequent centuries scientific inquiry has revealed an increasing number and complexity of entities, but the philosophical problem of the relative status of these entities has been largely ignored.

Here, the risk of pathogen invasion, and subsequent death from infection, was greatly increased as a result of wounding.

Fox tells the story from beginning to end: childhood in the German - American parsonage; nine grades of school followed by three years in a denominational «college» that was not yet a college and three year's in Eden Seminary, with graduation at 21; a five - month pastorate due to his father's death; Yale Divinity School, where despite academic probation because he had no accredited degree, he earned the B.D. and M.A.; the Detroit pastorate (1915 - 1918) in which he encountered industrial America and the race problem; his growing reputation as lecturer and writer (especially for The Christian Century); the teaching career at Union Theological Seminary (1928 - 1960); marriage and family; the landmark books Moral Man and Immoral Society and The Nature and Destiny of Man; the founding of the Fellowship of Socialist Christians and its journal Radical Religion; the gradual move from Socialist to liberal Democratic politics, and from leader of the Fellowship of Reconciliation to critic of pacifism; the break with Charles Clayton Morrison's Christian Century and the inauguration of Christianity and Crisis; the founding of the Union for Democratic Action, then later of Americans for Democratic Action; participation in the ecumenical movement, especially the Oxford Conference and the Amsterdam Assembly; increasing friendship with government officials and service with George Kennan's policy - planning group in the State Department; the first stroke in 1952 and the subsequent struggles with ill health; retirement from Union in 1960, followed by short appointments at Harvard, at the Center for the Study of Democratic Institutions, and at Columbia's Institute of War and Peace Studies; intense suffering from ill health; and death in Stockbridge, Massachusetts, in 1971.

, which resists all previous ages most successfully and dominates all subsequent ages most irresistibly, and thus is the real master of the human species... There neither is nor can be any simple increase of power on Man's side.

But mentality can discriminate either by ruling out, contradiction, or including, contrast, As mentality broadens, what were initially contradictions become contrasts.8 Mentality grows by the transmutation of contradiction into contrast, The increase in mental functioning begets in turn greater depth of contrast, which in its own turn further promotes mental functioning.9 This explains to some extent why it is not necessary to increase LSD dosage on subsequent occasions to promote greater effects.

In a recent human study, a large dose of resistant starch increased satiety and decreased subsequent food intake.

«All focus has been on the main river channel, with very little investigation of impacts on tributaries and subsequent increased duration of inundation.»

The current article shows that, with the use of all available data to date, acute exposure to experimental food advertising significantly increases subsequent food intake in children.

«The findings concerning identification and reporting,» said the authors of a 2013 study, [17] are particularly alarming given the growing body of both short - term and long - term issues associated with concussive injuries, such as psychological issues, school - related problems, increased risk of subsequent concussions and potential quality - of - life issues associated with concussions.»

The very large study of place of birth in the UK most recently showed no increase in risk for home birth for second or subsequent babies.

In a subsequent interview by Dana Woldow with Justin Gagnon, CEO of Choicelunch (a private school meal catering company), Gagnon, too, was very critical of the grain and meat limits, arguing that they encourage districts to increase the use of fats and fillers.

Clamping the cord, especially at an early stage, may also cause the extra blood trapped within the placenta to be forced back through the placenta into the mothers blood supply with the third stage contractions.32 33 This feto - maternal haemorrhage (FMH) increases the chance of future blood group incompatibility problems, which occur when the current baby's blood enters the mother's blood stream, causing an immune reaction which can be reactivated in a subsequent pregnancy, destroying the baby's blood cells and causing anaemia or even death.

I have recently read about breastfeeding promoting the regeneration and growth of glandular tissue removed during surgery, resulting in an increased milk supply for subsequent children.

Removing milk early after birth: this is important — pumping within the first hour of birth helps to remove more milk than pumping within the first six hours, and it increases significantly milk production in subsequent weeks

The incidence of placental abnormalities, such as placenta previa, in future pregnancies increases with each subsequent cesarean delivery, from 1 % with one prior cesarean delivery to almost 3 % with three or more prior cesarean deliveries.

With increasing frequency clients come for counselling to reconcile previous birth experiences that have left scars that hinder the joyous anticipation of subsequent children.

If this is a subsequent baby then her chance of c - section is not increased... but her chance of uterine rupture is.