Sentences with phrase «subunit expression»

GSEA demonstrated significant enrichment in NMDAR subunit expression both during hypoxia and following recovery.

HIPK2 - Mediated Transcriptional Control of NMDA Receptor Subunit Expression Regulates Neuronal Survival and Cell Death

Not exact matches

Suppressing the expression of even one of the many subunits making up the cap will impair the assembly of the whole cap, resulting in a proteasome - inhibitor resistant state.

Figure on the left: Analyzing the relative sensitivity of hundreds of cancer cell lines to commonly used anti-cancer drugs (each dot) reveals that cells with suppressed expression of one proteasome cap subunit are specifically resistant to treatments with the proteasome inhibitors MG132 and bortezomib.

The researchers found that, beyond conferring resistance to proteasome inhibitors, the suppressed expression of proteasome subunits reflects a broad remodeling of the cell's gene signature.

Figure on the right: Bortezomib treatment is significantly less effective in multiple myeloma patients who have suppressed expression of a 19s proteasome cap subunit.

Analyzing data from thousands of cancer lines and tumors, the researchers found that those demonstrating resistance to proteasome inhibitor drugs were marked by suppressed expression of one or more of the cells» proteasome cap subunits (which are a subsets of the larger proteasome).

Upon expression in cultured cells, the new subunits yielded prominent, typical glutamate - and NMDA - activated currents only when they were in heteromeric configurations with NR1.

«Telomerase is a unique protein - RNA complex where the protein subunit uses its RNA component as a template to add identical fragments of DNA to the end of chromosomes,» said Emmanuel Skordalakes, Ph.D., associate professor in the Gene Expression and Regulation program of Wistar's NCI - designated Cancer Center.

Class - specific inhibition of Gq - mediated signaling was produced in the hearts of transgenic mice by targeted expression of a carboxyl - terminal peptide of the α subunit Gαq.

The normal mice and the AS model mice with diminished expression of the Na / K - ATPase subunit searched the correct area of the maze in the same amount of time.

Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.

In the Cell Reports study, the authors hypothesized that if they could decrease expression of this subunit, they could improve cognitive function of AS model mice.

They examined behaviors of the following types of mice: normal mice, AS model mice, mice that had reduced levels of the Na / K - ATPase, and AS model mice in which expression of the subunit of Na / K - ATPase was reduced.

Examples of adipose tissue transcripts whose expression correlated with body mass include (a) Csf1r and (b) CD68 antigen (Cd68), which correlated positively with body mass, (c) succinate dehydrogenase complex, subunit B, iron sulfur (Ip)(Sdhb), and (d) ubiquinol — cytochrome c reductase subunit (Uqcr), which correlated negatively with body mass.

We found that genes encoding subunits of the Mg - chelatase complex and 3,8 - divinyl protochlorophyllide a 8 - vinyl reductase (DVR) likely function directly downstream of the GATAs and that DVR expression is limiting in the pale - green gnc gnl mutants.

Only NR1 mRNA expression could be detected in bipolar cells, and no NMDAR subunit mRNA expression was detected in rods [74].

Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.

We subsequently determined that expression of the SMARCA2 protein, another catalytic subunit of this complex, is also lost in all of these tumors.

The expression pattern of the individual NMDA - R subunits (NR1, NR2A, NR2B, NR2C, and NR2D) was further studied by quantitative real - time RT — PCR.

We found that the expression of distinct NMDAR subunit mRNAs was enriched in both hypoxic and post-hypoxia retina.

The Rel subunit of NF - kappaB - like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF - 1α, the regulatory subunit of HIF - 1, and increased VEGF expression have been shown, indicating that HIF - 1 may control the expression of VEGF in the retina under hypoxic conditions.

We use our mammalian expression technologies to create panels of recombinant pathogen proteins that are then used to identify new subunit vaccine targets for infectious diseases.

Repeated intermittent alcohol exposure during the third trimester - equivalent increases expression of the GABA < sub > A receptor δ subunit in cerebellar granule neurons and delays motor development in rats.

All muscle fibers exhibit complex II immunoreactivity, consistent with the nuclear DNA - encoded expression pattern of this and all other subunits of complex II.

van der Lee R, Szklarczyk R, Smeitink J, Smeets HJ, Huynen MA, Vogel R. Transcriptome analysis of complex I - deficient patients reveals distinct expression programs for subunits and assembly factors of the oxidative phosphorylation system.

Repeated intermittent alcohol exposure during the third trimester - equivalent increases expression of the GABA A receptor δ subunit in cerebellar granule neurons and delays motor development in rats.

Results demonstrated that the Met subunit is highly dynamic in controlling the action of methyl farnesoate through temporal variation in its expression and availability for receptor assembly.

Expression of the α3, α4, and α7 nAChR subunits in cerebellar cultured cells was examined by RT - PCR.

The interaction of NSF with the C - terminus of the GluA2 subunit of the AMPA receptor was first uncovered by yeast two - hybrid screening and was quickly shown to be an important factor in the regulation of AMPA receptor surface expression (Nishimune et al 1998, Noel et al 1999) as well as LTD in the hippocampus (Luthi et al 1999) and cerebellum (Steinberg et al 2004).

The expression of micro-RNA miR - 663 was induced by mitochondrial reactive oxygen species production, an apoptotic signal and oxidative stress response, and miR - 663 induced the expression of nuclear - encoded mitochondrial respiratory chain subunits.

From the widespread and overlapping expression patterns of UNC - 7S and UNC - 9, it appeared likely that both of these innexins contribute subunits to most of the gap junctions in the locomotory nervous system.

H: Quantification of percentages of neurons with nuclear expression of ZENK within each subunit.

Comparison of gene expression profiles indicate that both the SLC2A1 and CLICl receptor subunit transcripts are expressed at significantly higher levels in NSCs but not in differentiated neurons, suggesting that NSCs may be more sensitive to the channel - effects of amiodarone HCL.

Because subunit composition can influence the docking between hemichannels [14], it might be possible to pattern synaptic connections through selective expression of innexins, of which 25 exist in C. elegans (reviewed in [1]-RRB-.

Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4).