Sentences with phrase «such fibrils»
Such fibrils form plaques, or areas of tissue damage, that researchers can observe with microscopes.
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The structures, called amyloid fibrils, are also implicated in neurodegenerative conditions such as Alzheimer's and Parkinson's, and in prion diseases like Creutzfeldt - Jacob and mad cow disease.
«Fibrils are remarkably strong and, as such, are a good barometer for this method's ability to form two - dimensional structures,» observes Seeman.
If the newly discovered beta - sheet structure idea could be integrated as building blocks into such artificially designed proteins, it would improve their ability to attach to the disease - causing fibrils — a first step in the development of new agents against Alzheimer's and other neurodegenerative diseases.
«NMR enabled us to obtain additional information such as which amino acid residues form salt bridges thus enhancing the stability of the fibrils,» explains Prof. Henrike Heise from Heinrich Heine University Düsseldorf and Jülich's Biomolecular NMR Center.
«Amyloid fibrils are normally only found in diseases caused by protein misfolding, such as Alzheimer's or Parkinson's disease, so the natural presence of multiple amyloids in the semen of healthy men was completely unexpected,» said Warner C. Greene, MD, PhD, senior investigator and director of the Gladstone Institute of Virology and Immunology.
A 2009 study published in the «Journal of Agricultural and Food Chemistry» showed that nattokinase was able to degrade amyloid fibrils in vitro and may potentially be useful for treating amyloid - related diseases such as Alzheimer's disease.