Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1 / TSC2 tumor
suppressor complex
Schaefer, A.; Sampath, S. C.; Intrator, A.; Min, A.; Gertler, T. S.; Surmeier, D. J.; Tarakhovsky, A.; Greengard, P. Control of Cognition and Adaptive Behavior by the GLP / G9a Epigenetic
Suppressor Complex.
«A Tumor
Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1»
Not exact matches
These
complexes lead to mutations in the TP53 tumor
suppressor gene, which in turn initiate the process toward kidney cancer.
The tumor
suppressor protein APC forms the core of a cytoplasmic
complex which binds ß - catenin and targets it for degradation in the proteasome.
The highly homologous bromodomain containing protein 7 (BRD7) is a component of the SWI / SNF polybromo - associated BAF (PBAF)
complex and has been proposed as a tumor
suppressor [2].
The tumor
suppressor BAP1 associates with ASXL1 / 2 to form the core Polycomb
complex PR - DUB, which catalyzes the removal of mono - ubiquitin from several substrates including histone H2A.
These results indicate the importance of assessing miR function in the
complex physiology of in vivo model systems and indicate that further functional testing of miR - 342 is required before concluding it is a bona fide tumor -
suppressor - miR.