Sentences with phrase «syn lewy»
The major significance of the paper is that it resolves the long - standing controversy about the role of α - Syn Lewy bodies in the degeneration of substantia nigra dopamine neurons, thereby sharpening the focus on Lewy bodies as targets for discovery of disease modifying therapy for Parkinson patients.
https://www.pennmedicine.org/ Not exact matches
«The Lewy bodies are big aggregates and they're sitting in the cell, but they don't come into direct contact with the mitochondria in the way pα - syn * does,» Lasmézas explains.
The cell culture experiments showed that MAbs prevented the uptake of misfolded α - syn fibrils by neurons and sharply reduced the recruitment of natural α - syn into new Lewy body aggregates.
In time, α - Syn forms the characteristic Lewy bodies in the neurons of patients with PD and some other neurodegenerative disorders.