Title:
Synaptic transmission changes in fear memory circuits underlie key features of an animal model of schizophrenia Author: M. Pollard et al..
Not exact matches
Consistent with recent studies of such
changes, we find that long - lasting potentiation of
synaptic transmission between cultured hippocampal neurons is accompanied by an increase in the number of clusters of postsynaptic glutamate receptors containing the subunit GluR1.
It is «tempting to speculate that crucial aspects of
synaptic transmission may have
changed in modern humans,» the team wrote.
Unexpectedly, these behavioral
changes were accompanied by an increase in inhibitory
synaptic transmission with no apparent effect on excitatory synapses.
We are particularly interested in an emotional stress - induced
change in endocannabinoid signaling and
synaptic transmission and the effects of stress on the activity of a neuronal circuitthat is associated with learning / memory (see J. Neurosci.31: 501, 2011, 29:381, 2009; Nature Neurosci.
Changes in the abundance of these receptors alter
synaptic transmission in the aged brain.
It is therefore essential to understand how
changes in
synaptic transmission can regulate the organization and dynamics of actin binding proteins (ABPs).
Kauwe and others in Haghighi's lab are exploring why such a
change in the set point of
synaptic transmission occurs so rapidly, and how dampening neuron activity might be beneficial in treating, or even preventing, neurodegenerative diseases.