Sentences with phrase «t cell accumulation»

PEGylated arginine deiminase can modulate tumor immune microenvironment by affecting immune checkpoint expression, decreasing regulatory T cell accumulation and inducing tumor T cell infiltration.

Not exact matches

«This was associated with an unexpected accumulation of T - cells in the lungs of infected mice that lack STIM1.»

Vitiligo is characterised by the accumulation of a subgroup of T cells called CD49a +, which recognise and are ready to kill pigment cells.

In vitro experiments indicated that the antihistamines work by suppressing the accumulation and function of dendritic cells, which take up peanut protein and present it to T cells of the immune system.

Haruo Ohtani and colleagues at the Kitasato University School of Medicine in Japan publish a landmark study showing that the presence and location of CD8 + tumor - infiltrating lymphocytes (TILs) correlates with prognosis in colon cancers, specifically that the accumulation of CD8 + T cells within the tumor predicted improved patient survival, whereas accumulation of the same cells in the tumor periphery did not correlate with survival.

Survival was longer and there was a significantly lower number of MDSCs, which also had lower ability to suppress T cells, thus suggesting that soluble antibodies are responsible for accumulation of immune suppressive MDSCs.

After encountering HO - 1 (+) MoDCs, effector T - cells exhibited a lower velocity and a reduced ability to migrate towards chemokine gradients resulting in impaired accumulation to the inflamed organ.

Finally, we demonstrate that treatment of T - 47D cells with epidermal growth factor (EGF), which promotes cell ruffling, stimulates increased accumulation of activated matriptase at the sites of membrane ruffling, suggesting a possible functional role at these sites.

SDF - 1 is expressed in synovial epithelial cells and it has been reported that persistent induction of CXCR4 by stromal derived factors, such as TGF - β led to SDF - 1 mediated accumulation of CD4 T cells within the rheumatoid joint [44].

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

These mice develop spontaneous autoimmune - like signs, including splenomegaly, accumulation of activated T cells and autoantibodies, and pathological features of inflammation in the intestine.

Tryptophan depletion results in the inhibition of effector T cells and kynurenine accumulation results in the expansion of immune - suppressant regulatory T cells.

In 2008, he obtained his Ph.D. from the University of Southampton, United Kingdom, where he studied the mechanisms of accumulation and activation of T cells in human asthma.

The etiology of immune senescence is unknown but the accumulation of virus - specific memory T cells may be a contributory factor.

This demonstrates that aging is associated with a marked accumulation of CMV - specific CD8 T cells together with a decrease in immediate effector function.

The accumulation of dysfunctional CMV - specific cells might fill the «immunological space» and decrease the available repertoire of T cells for novel antigens.

Thus, T cell responses are altered in the aged by an accumulation of replicatively senescent dysfunctional T cells carrying receptors for persistent herpes viruses.

Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging